Intrinsic and damage-induced JAK/STAT signaling regulate developmental timing by the Drosophila prothoracic gland.
Intrinsic and damage-induced JAK/STAT signaling regulate developmental timing by the Drosophila prothoracic gland.
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内在和损伤诱导的 JAK/STAT 信号调节果蝇前胸腺的发育时间
DOI：
10.1242/dmm.049160
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发表时间：
2022-01-01
影响因子：
4.3
通讯作者：
Pastor-Pareja JC
中科院分区：
文献类型：
--
作者：
Cao X;Rojas M;Pastor-Pareja JC
发展包括节奏紧凑、可重复的事件序列，但它必须适应外部条件，如资源可用性和机体损伤。在脊椎动物和昆虫中，损伤诱导的免疫反应的主要媒介是JAK/STAT信号。同时，果蝇Upd细胞因子对JAK/STAT的激活多效性参与了多器官的正常发育。炎症性和发育性JAK/STAT的作用是否交叉是未知的。在这里，我们发现JAK/STAT在前胸腺（PG）的发育过程中是活跃的，前胸腺通过蜕皮激素的产生控制变态的发生。减少JAK/STAT信号减少PG大小和晚期变态。相反，JAK/STAT因通路组分过表达或SUMOylation缺失而过度激活，导致PG肥大和变态延迟。组织损伤和肿瘤，已知会分泌Upd细胞因子，也激活PG中的JAK/STAT并延迟变态，至少部分是通过诱导JAK/STAT靶细胞Apontic的表达。因此，JAK/STAT损伤信号通过选择其在PG中的发育作用来调节变态的发生。我们在果蝇中的研究结果为损伤和癌症的系统性影响如何干扰激素控制的发育和发育转变提供了见解。摘要：JAK/STAT激活的Upd细胞因子介导的肿瘤损伤信号通过共同选择JAK/STAT在前胸腺的发育作用，延迟了果蝇幼虫到蛹的转变。
Development involves tightly paced, reproducible sequences of events, yet it must adjust to conditions external to it, such as resource availability and organismal damage. A major mediator of damage-induced immune responses in vertebrates and insects is JAK/STAT signaling. At the same time, JAK/STAT activation by the Drosophila Upd cytokines is pleiotropically involved in normal development of multiple organs. Whether inflammatory and developmental JAK/STAT roles intersect is unknown. Here, we show that JAK/STAT is active during development of the prothoracic gland (PG), which controls metamorphosis onset through ecdysone production. Reducing JAK/STAT signaling decreased PG size and advanced metamorphosis. Conversely, JAK/STAT hyperactivation by overexpression of pathway components or SUMOylation loss caused PG hypertrophy and metamorphosis delay. Tissue damage and tumors, known to secrete Upd cytokines, also activated JAK/STAT in the PG and delayed metamorphosis, at least in part by inducing expression of the JAK/STAT target Apontic. JAK/STAT damage signaling, therefore, regulates metamorphosis onset by co-opting its developmental role in the PG. Our findings in Drosophila provide insights on how systemic effects of damage and cancer can interfere with hormonally controlled development and developmental transitions. Summary: Damage signaling from tumors mediated by JAK/STAT-activating Upd cytokines delays the Drosophila larva–pupa transition through co-option of a JAK/STAT developmental role in the prothoracic gland.
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DOI：
10.1016/j.cub.2010.01.038
发表时间：
2010-03-09
期刊：
Current biology : CB
影响因子：
--
作者：
Halme A;Cheng M;Hariharan IK
通讯作者：
Hariharan IK
影响因子：
4.5
作者：
Akai N;Ohsawa S;Sando Y;Igaki T
通讯作者：
Igaki T
影响因子：
1.2
作者：
Bach, Erika A.;Ekas, Laura A.;Baeg, Gyeong-Hun
通讯作者：
Baeg, Gyeong-Hun
影响因子：
11.4
作者：
Eulenberg, KG;Schuh, R
通讯作者：
Schuh, R
影响因子：
9.2
作者：
Boulan, Laura;Martin, David;Milan, Marco
通讯作者：
Milan, Marco