Neural activations during self-related processing in patients with chronic pain and effects of a brief self-compassion training - A pilot study.
Neural activations during self-related processing in patients with chronic pain and effects of a brief self-compassion training - A pilot study.
复制标题
DOI：
10.1016/j.pscychresns.2020.111155
复制
发表时间：
2020-10-30
期刊：
影响因子：
--
通讯作者：
Schuman-Olivier Z
中科院分区：
文献类型：
--
作者：
Lutz J;Berry MP;Napadow V;Germer C;Pollak S;Gardiner P;Edwards RR;Desbordes G;Schuman-Olivier Z
Chronic pain negatively affects psychological functioning including self-perception. Self-compassion may improve self-related functioning in patients with chronic pain but understanding of the neural mechanisms is limited. In this study, twenty patients with chronic low back pain read negative self-related situations and were instructed to be either self-reassuring or self-critical while undergoing fMRI. Patients rated their feelings of self-reassurance and self-criticism during each condition, and brain responses were contrasted with neutral instructions. Trait self-compassion measures (SCS) were also acquired. Brain activations during self-criticism and self-reassurance were localized to prefrontal, self- and emotion-processing areas, such as medial prefrontal cortex, dorsolateral prefrontal cortex (dlPFC), dorsal anterior cingulate cortex and posterior cingulate cortex. Self-reassurance resulted in more widespread and stronger activations relative to self-criticism. Patients then completed a brief self-compassion training (8 contact hours, 2 weeks home practice). Exploratory pre-post comparisons in thirteen patients found that feelings of self-criticism were significantly reduced and brain activations were greater in the anterior insula and prefrontal cortical regions such as dlPFC. Pre-post increases in dlPFC activation correlated with increased self-compassion (SCS), suggesting that early self-compassion skills might primarily target self-criticism via dlPFC upregulation. Future controlled studies on self-compassion training in chronic pain populations should extend these results.
登录
查看更多内容
DOI：
10.1093/cercor/bhq186
发表时间：
2011-07
期刊：
Cerebral cortex (New York, N.Y. : 1991)
影响因子：
--
作者：
Deen B;Pitskel NB;Pelphrey KA
通讯作者：
Pelphrey KA
影响因子：
12.8
作者：
Hofmann, Stefan G.;Grossman, Paul;Hinton, Devon E.
通讯作者：
Hinton, Devon E.
影响因子：
3.7
作者：
Hooley JM;Siegle G;Gruber SA
通讯作者：
Gruber SA
影响因子：
3.5
作者：
Gorgolewski KJ;Varoquaux G;Rivera G;Schwarz Y;Ghosh SS;Maumet C;Sochat VV;Nichols TE;Poldrack RA;Poline JB;Yarkoni T;Margulies DS
通讯作者：
Margulies DS
影响因子：
4.1
作者：
Kuyken, Willem;Watkins, Ed;Dalgleish, Tim
通讯作者：
Dalgleish, Tim