Affective and neural reactivity to criticism in individuals high and low on perceived criticism.
Affective and neural reactivity to criticism in individuals high and low on perceived criticism.
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DOI：
10.1371/journal.pone.0044412
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Gruber SA
中科院分区：
文献类型：
--
作者：
Hooley JM;Siegle G;Gruber SA
如果抑郁症已经缓解的人根据感知批评（PC）的简单自我报告衡量其亲属对他们的批评，那么他们复发的风险就会增加。为了探索与此相关的神经机制，我们使用功能磁共振成像 (fMRI) 来检查具有不同 PC 水平的人对听到自己母亲的批评有何反应。为了最大限度地提高情感反应的变异性，抑郁症患者、抑郁症康复者和健康对照参与者 (n = 33) 根据中位数划分将 PC 分为高或低。然后，他们会听到来自母亲的与个人相关的批评和赞扬评论。批评感知水平与抑郁状态以及听到批评后的负面情绪变化无关。然而，与低 PC 参与者相比，那些在 PC 上得分高的人在与情绪反应和调节相关的区域网络中表现出差异激活，包括杏仁核活动增加和前额叶调节区域在听到批评时反应减少。这不是值得赞扬的情况。批评可能是复发的危险因素，因为它有助于“训练”抑郁信息处理的特征路径。感知批评措施可能有助于识别更容易受到此漏洞影响的人。
People who have remitted from depression are at increased risk for relapse if they rate their relatives as being critical of them on a simple self-report measure of Perceived Criticism (PC). To explore neural mechanisms associated with this we used functional magnetic resonance imaging (fMRI) to examine how people with different levels of PC responded to hearing criticism from their own mothers. To maximize variability in affective reactivity, depressed, recovered depressed, and healthy control participants (n = 33) were classified as high or low in PC based on a median split. They were then exposed to personally-relevant critical and praising comments from their mothers. Perceived Criticism levels were unrelated to depression status and to negative mood change after hearing criticism. However, compared to low PC participants, those who scored high on PC showed differential activation in a network of regions associated with emotion reactivity and regulation, including increased amygdala activity and decreased reactions in prefrontal regulatory regions when they heard criticism. This was not the case for praise. Criticism may be a risk factor for relapse because it helps to “train” pathways characteristic of depressive information processing. The Perceived Criticism measure may help identify people who are more susceptible to this vulnerability.
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