Establishment and cryptic transmission of Zika virus in Brazil and the Americas.
Establishment and cryptic transmission of Zika virus in Brazil and the Americas.
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DOI：
10.1038/nature22401
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发表时间：
2017-06-15
期刊：
影响因子：
64.8
通讯作者：
Pybus OG
中科院分区：
文献类型：
--
作者：
Faria NR;Quick J;Claro IM;Thézé J;de Jesus JG;Giovanetti M;Kraemer MUG;Hill SC;Black A;da Costa AC;Franco LC;Silva SP;Wu CH;Raghwani J;Cauchemez S;du Plessis L;Verotti MP;de Oliveira WK;Carmo EH;Coelho GE;Santelli ACFS;Vinhal LC;Henriques CM;Simpson JT;Loose M;Andersen KG;Grubaugh ND;Somasekar S;Chiu CY;Muñoz-Medina JE;Gonzalez-Bonilla CR;Arias CF;Lewis-Ximenez LL;Baylis SA;Chieppe AO;Aguiar SF;Fernandes CA;Lemos PS;Nascimento BLS;Monteiro HAO;Siqueira IC;de Queiroz MG;de Souza TR;Bezerra JF;Lemos MR;Pereira GF;Loudal D;Moura LC;Dhalia R;França RF;Magalhães T;Marques ET Jr;Jaenisch T;Wallau GL;de Lima MC;Nascimento V;de Cerqueira EM;de Lima MM;Mascarenhas DL;Neto JPM;Levin AS;Tozetto-Mendoza TR;Fonseca SN;Mendes-Correa MC;Milagres FP;Segurado A;Holmes EC;Rambaut A;Bedford T;Nunes MRT;Sabino EC;Alcantara LCJ;Loman NJ;Pybus OG
寨卡病毒在美洲的传播于2015年5月在巴西东北部首次得到确认。巴西是全球报告寨卡病毒病例最多的国家（截至2016年12月24日超过20万例），与小头畸形和其他出生缺陷相关的病例最多（截至2016年12月31日确诊2366例）。自在巴西首次发现寨卡病毒以来，美洲超过45个国家报告了当地寨卡病毒传播，其中24个国家报告了严重的寨卡病毒相关疾病。然而，寨卡病毒在巴西和美洲的起源和流行历史仍然知之甚少，尽管这些信息对于解释观察到的小头畸形报告趋势具有价值。在这里，我们通过生成54个完整或部分寨卡病毒基因组（主要来自巴西）来解决这一问题，并报告了2016年在巴西东北部旅行的移动基因组学实验室生成的数据。其中一个序列代表巴西最早确认的寨卡病毒感染。对具有生态和流行病学数据的病毒基因组进行的分析得出的估计是，到2014年2月，寨卡病毒已经在巴西东北部出现，并且很可能在美洲首次发现寨卡病毒之前从那里在国内和国际上传播。巴西寨卡病毒国际传播的估计日期表明在感染区域发现前的隐传持续时间。对寨卡病毒传播潜力的地理分析和对该病毒基本繁殖数量的估计进一步支持了巴西东北部在美洲确立寨卡病毒传播方面的作用。
Transmission of Zika virus (ZIKV) in the Americas was first confirmed in May 2015 in northeast Brazil. Brazil has had the highest number of reported ZIKV cases worldwide (more than 200,000 by 24 December 2016) and the most cases associated with microcephaly and other birth defects (2,366 confirmed by 31 December 20162). Since the initial detection of ZIKV in Brazil, more than 45 countries in the Americas have reported local ZIKV transmission, with 24 of these reporting severe ZIKV-associated disease. However, the origin and epidemic history of ZIKV in Brazil and the Americas remain poorly understood, despite the value of this information for interpreting observed trends in reported microcephaly. Here we address this issue by generating 54 complete or partial ZIKV genomes, mostly from Brazil, and reporting data generated by a mobile genomics laboratory that travelled across northeast Brazil in 2016. One sequence represents the earliest confirmed ZIKV infection in Brazil. Analyses of viral genomes with ecological and epidemiological data yield an estimate that ZIKV was present in northeast Brazil by February 2014 and is likely to have disseminated from there, nationally and internationally, before the first detection of ZIKV in the Americas. Estimated dates for the international spread of ZIKV from Brazil indicate the duration of pre-detection cryptic transmission in recipient regions. The role of northeast Brazil in the establishment of ZIKV in the Americas is further supported by geographic analysis of ZIKV transmission potential and by estimates of the basic reproduction number of the virus.
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DOI：
10.1126/science.aaf5036
发表时间：
2016-04-15
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Faria NR;Azevedo RDSDS;Kraemer MUG;Souza R;Cunha MS;Hill SC;Thézé J;Bonsall MB;Bowden TA;Rissanen I;Rocco IM;Nogueira JS;Maeda AY;Vasami FGDS;Macedo FLL;Suzuki A;Rodrigues SG;Cruz ACR;Nunes BT;Medeiros DBA;Rodrigues DSG;Queiroz ALN;da Silva EVP;Henriques DF;da Rosa EST;de Oliveira CS;Martins LC;Vasconcelos HB;Casseb LMN;Simith DB;Messina JP;Abade L;Lourenço J;Alcantara LCJ;de Lima MM;Giovanetti M;Hay SI;de Oliveira RS;Lemos PDS;de Oliveira LF;de Lima CPS;da Silva SP;de Vasconcelos JM;Franco L;Cardoso JF;Vianez-Júnior JLDSG;Mir D;Bello G;Delatorre E;Khan K;Creatore M;Coelho GE;de Oliveira WK;Tesh R;Pybus OG;Nunes MRT;Vasconcelos PFC
通讯作者：
Vasconcelos PFC
影响因子：
5.4
作者：
Holmes, EC
通讯作者：
Holmes, EC
影响因子：
3.8
作者：
Faye O;Freire CC;Iamarino A;Faye O;de Oliveira JV;Diallo M;Zanotto PM;Sall AA
通讯作者：
Sall AA
DOI：
10.1016/j.cub.2011.05.058
发表时间：
2011-08-09
期刊：
Current biology : CB
影响因子：
--
作者：
Edwards CJ;Suchard MA;Lemey P;Welch JJ;Barnes I;Fulton TL;Barnett R;O'Connell TC;Coxon P;Monaghan N;Valdiosera CE;Lorenzen ED;Willerslev E;Baryshnikov GF;Rambaut A;Thomas MG;Bradley DG;Shapiro B
通讯作者：
Shapiro B
影响因子：
3.8
作者：
Hoang Quoc Cuong;Nguyen Tran Hien;Horby, Peter
通讯作者：
Horby, Peter