Fast radio-frequency enforced steady state (FRESS) spin echo MRI for quantitative T2 mapping: minimizing the apparent repetition time (TR) dependence for fast T2 measurement.
Fast radio-frequency enforced steady state (FRESS) spin echo MRI for quantitative T2 mapping: minimizing the apparent repetition time (TR) dependence for fast T2 measurement.
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DOI：
10.1002/nbm.1729
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发表时间：
2012-02
影响因子：
2.9
通讯作者：
Sun, Phillip Zhe
中科院分区：
文献类型：
--
作者：
Cheung, Jerry S.;Wang, Enfeng;Zhang, XiaoAn;Mandeville, Emiri;Lo, Eng H.;Sorensen, A. Gregory;Sun, Phillip Zhe
横向弛豫时间（T2）是一个基本但非常有用的MRI参数，广泛用于成像检查许多疾病，包括多发性硬化症，中风和肿瘤。然而，通常使用短重复时间（TR）来最小化扫描时间，这可能在T2测量中引入不可忽略的误差。具体地，由于使用重聚焦脉冲，稳态磁化不仅取决于TR，而且取决于TE。因此，如果TE依赖性没有被正确地考虑，它可能被误认为是T2诱导的信号衰减，导致不可忽略的T2低估。我们的研究提出了一种快速射频强制稳态（FRESS）自旋回波（SE）MRI序列，它在回波后饱和磁化并确保TE独立的稳态。建议的FRESS-SE MRI进行了评估与数值模拟，实现与回波平面成像读出，并验证了体模和体内实验。综上所述，FRESS-SE T2 MRI技术是为快速和准确的T2成像而开发的，适合于体内应用。
Transverse relaxation time (T2) is a basic but very informative MRI parameter, widely used in imaging to examine a host of diseases, including multiple sclerosis, stroke, and tumor. However, short repetition time (TR) is often used to minimize scan time, which may introduce non-negligible errors in T2 measurement. Specifically, due to the use of refocusing pulse, the steady state magnetization depends not only on TR but also on the TE. Hence, if the TE dependence is not properly accounted for, it may be mistaken as T2-induced signal attenuation, leading to non-negligible T2 underestimation. Our study proposed a fast radio-frequency enforced steady state (FRESS) spin echo (SE) MRI sequence, which saturates the magnetization after the echo and ensures a TE-independent steady state. The proposed FRESS-SE MRI was evaluated with numerical simulation, implemented with echo planar imaging readout, and validated by both phantom and in vivo experiments. In summary, FRESS-SE T2 MRI technique was developed for fast and accurate T2 imaging, suitable for in vivo applications.
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