Basolateral amygdala and morphine-induced taste avoidance in the rat.

Basolateral amygdala and morphine-induced taste avoidance in the rat.
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DOI:
10.1016/j.physbeh.2009.12.007
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发表时间:
2010-03-03
影响因子:
2.9
通讯作者:
Reilly, Steve
Reilly, Steve
中科院分区:
医学3区
文献类型:
--
作者:
Lovaglio, Jamie;Lin, Jian-You;Roman, Christopher;Reilly, Steve

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本实验研究了基底外侧杏仁核(BLA)兴奋性毒性损伤对吗啡诱导的糖精回避的影响。神经系统完好的受试者很快学会了避免饮用味觉条件刺激(CS),这种效果在整个实验中一直持续。尽管在最初的几次试验中,BLAX损伤的大鼠表现出CS回避,但这种效果并不持久。也就是说,到实验结束时,BLAX大鼠在七次糖精-吗啡试验后饮用与第一次试验相同量的糖精(即,在注射吗啡之前)。潜在的解释的结果进行了讨论,包括中断的机制,管理药物诱导的味觉回避在正常受试者和更快速的发展,在BLAX大鼠的耐受性。
The present experiment examined the influence of excitotoxic lesions of the basolateral amygdala (BLA) on morphine-induced saccharin avoidance. Neurologically intact subjects rapidly learned to avoid drinking the taste conditioned stimulus (CS), an effect that was sustained throughout the experiment. Although the BLA-lesioned (BLAX) rats showed CS avoidance over the first few trials, the effect was not sustained. That is, by the end of the experiment, the BLAX rats were drinking the same amount of saccharin after seven saccharin-morphine trials as they did on the first trial (i.e., prior to the morphine injections). Potential interpretations of the results are discussed including a disruption of the mechanism that governs drug-induced taste avoidance in normal subjects and the more rapid development of tolerance in BLAX rats.
DOI: 10.1007/s00213-002-1196-x
发表时间: 2003-07-01
期刊: PSYCHOPHARMACOLOGY
影响因子: 3.4
作者:
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通讯作者: See, RE
DOI: 10.1037/h0033316
发表时间: 1972-01-01
期刊: JOURNAL OF COMPARATIVE AND PHYSIOLOGICAL PSYCHOLOGY
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发表时间: 1997-02-01
影响因子: 1.9
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DOI: 10.1016/0006-8993(74)90309-6
发表时间: 1974-01-01
期刊: BRAIN RESEARCH
影响因子: 2.9
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通讯作者: PRICE, JL