Vasodilator effects of adrenomedullin on small pulmonary arteries and veins in anaesthetized cats
Vasodilator effects of adrenomedullin on small pulmonary arteries and veins in anaesthetized cats
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肾上腺髓质素对麻醉猫小肺动脉和静脉的血管扩张作用
DOI：
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发表时间：
1997
影响因子：
7.3
通讯作者：
H. Matsuo
中科院分区：
文献类型：
--
作者：
M. Shirai;A. Shimouchi;S. Ikeda;I. Ninomiya;K. Sunagawa;K. Kangawa;H. Matsuo
本研究旨在确定肾上腺髓质素（AM）在肺血管床的作用部位及其扩血管作用与血管张力的关系。此外，检查降钙素基因相关肽（CGRP）受体是否介导AM诱导的肺血管舒张。为此，我们直接测量内径（i.d.）肺小动脉和静脉（100-1100 μm i.d.）的变化通过在体内猫肺上使用X射线电视系统。在对照（静息血管张力）条件下，AM注射至左主肺动脉引起剂量相关的i.d.在小动脉和静脉中增加。平均ID无论AM的注射剂量如何，100-1100 μm动脉的增加（0.01、0.1和1 nmol kg-1 AM分别为4±1、11±2和17± 2%）均显着大于静脉（0.01、0.1和1 nmol kg-1 AM分别为1±1、5±2和7±2%）。当缺氧（5%O_2）使i.d. 100-1100 μm动脉和静脉中，AM（0.1 nmol kg−1）分别减少16± 3%和6± 3%，能够诱导显著更大的i.d.与对照条件下相比，动脉（28±3%）和静脉（11±3%）增加。AM诱导的i.d.串联肺动脉的反应模式与CGRP的反应模式不同，AM引起的小血管（100-500 μm）的反应比大血管（500-1100 μm）的反应更强。在CGRP的情况下，在较大的血管中观察到更大的增加。CGRP 8 -37（100 nmol kg-1，i.v.，随后连续输注0.2 nmol kg-1 min-1）对i.d.在动脉和静脉的任何连续节段中，AM（0.1 nmol kg−1）诱导的增加。结果表明，在猫中，AM引起小肺动脉的血管扩张较大，小静脉的血管扩张较小，最大扩张位于外周动脉段（100-500 μm）。血管张力增高时，AM的扩血管作用增强。提示AM诱导的肺血管舒张不是由CGRP受体介导的，而是由其自身特异性受体介导的。
This study was conducted to determine adrenomedullin (AM) action sites in the pulmonary vascular bed and the relation between its vasodilator effects and vascular tone. Moreover, an examination was made into whether calcitonin gene‐related peptide (CGRP) receptors mediate pulmonary vasodilatations induced by AM. To this end, we directly measured internal diameter (i.d.) changes in small pulmonary arteries and veins (100–1100 μm i.d.) by use of an X‐ray televison system on the in vivo cat lung. Under control (resting vascular tone) conditions, AM injections into the left main pulmonary artery caused dose‐related i.d. increases in both small arteries and veins. The mean i.d. increase of the 100–1100 μm arteries (4±1, 11±2, and 17±2% with 0.01, 0.1, and 1 nmol kg−1 AM, respectively) was significantly larger than that for the veins (1±1, 5±2, and 7±2% with 0.01, 0.1 and 1 nmol kg−1 AM, respectively) whatever the injected dose of AM. When unilobar hypoxia (5% O2) had decreased the i.d. of the 100–1100 μm arteries and veins by 16±3 and 6±3%, respectively, AM (0.1 nmol kg−1) was able to induce significantly larger i.d. increases in the arteries (28±3%) and veins (11±3%) than those under control conditions. The AM‐induced i.d. response pattern in the serially connected pulmonary arteries was quite different from that induced by CGRP; AM caused a greater increase in smaller vessels (100–500 μm) than in larger vessels (500–1100 μm). In the case of CGRP, a greater increase was observed in the larger vessels. CGRP8–37 (100 nmol kg−1, i.v., followed by a continuous infusion of 0.2 nmol kg−1 min−1) had no significant effect on the i.d. increase induced by AM (0.1 nmol kg−1) in any serial segments of the arteries and veins. The results indicate that, in the cat, AM induces greater vasodilatation in small pulmonary arteries and lesser vasodilatation in small veins, the maximum dilatation being in the more peripheral arterial segment (100–500 μm). The vasodilator effect of AM was enhanced when vascular tone was elevated. The data suggest that the AM‐induced pulmonary vasodilatation is not mediated by CGRP receptors but by its own specific receptor.
大鼠肠系膜拱形小动脉扩张器对血流速度增加的反应。
DOI：
10.1152/ajpheart.1989.257.6.h1958
发表时间：
1989
期刊：
The American journal of physiology
影响因子：
--
作者：
Smiesko,V;Lang,DJ;Johnson,PC
通讯作者：
Johnson,PC
静脉注射降钙素基因相关肽（CGRP）对猫局部血流的影响。
DOI：
10.1111/j.1748-1716.1989.tb08747.x
发表时间：
1989
期刊：
Acta physiologica Scandinavica
影响因子：
--
作者：
Andersson,SE
通讯作者：
Andersson,SE
肾上腺髓质素 (ADM) 片段保留了人 ADM 的全身血管舒张活性。
影响因子：
6.1
作者：
Hao,Q;Chang,JK;Gharavi,H;Fortenberry,Y;Hyman,A;Lippton,H
通讯作者：
Lippton,H