Aging reduces the sensitivity to the reinforcing efficacy of morphine.
Aging reduces the sensitivity to the reinforcing efficacy of morphine.
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DOI：
10.1016/j.neurobiolaging.2020.09.020
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发表时间：
2021-01
影响因子：
4.2
通讯作者：
Wimmer ME
中科院分区：
文献类型：
--
作者：
Bongiovanni AR;Peer K;Carpenter RE;Ellis AS;Duggan MR;Parikh V;Wimmer ME
美国老年人口正在增长，使用的阿片类药物比以往任何时候都多。本研究的目的是确定是否老化的影响，加强效力的吗啡在雄性和雌性大鼠使用啮齿类动物静脉自我管理的范例。以两种剂量（0.75mg/kg/输注和0.25mg/kg/输注）对雄性和雌性老年（20- 2-4月龄）和年轻（2-4月龄）Wistar大鼠进行了试验。在10天的自我给药期间，老年大鼠在0.25mg/kg/输注剂量下比年轻大鼠服用的吗啡显著减少。在此剂量下，老年男性在渐进式定量强化计划中的输注量也显著减少，表明在此剂量下，该组吗啡的强化功效降低。当单独一组动物接受0.75 mg/kg/输注剂量时，这些影响消失。我们的研究结果表明，吗啡在老年雄性大鼠中在较低剂量下的增强作用较小，但在雌性大鼠中则不然。这项研究对老年人阿片类药物的慢性治疗具有潜在的临床意义。
The US geriatric population is growing and using more opioids than ever before. The purpose of this study was to determine whether aging influenced the reinforcing efficacy of morphine in male and female rats using a rodent intravenous self-administration paradigm. Male and female aged (20–24 months) and young (2–4 months) Wistar rats were tested at two doses of morphine (0.75mg/kg/infusion and 0.25mg/kg/infusion). During 10 days of self-administration, aged rats took significantly less morphine than their younger counterparts at the 0.25mg/kg/infusion dose. Aged males also earned significantly fewer infusions on a progressive ration reinforcement schedule at this dose, suggesting that the reinforcing efficacy of morphine is decreased for this group at this dose. These effects dissipated when a separate group of animals had access to the 0.75mg/kg/infusion dose for both sexes. Our results indicate that morphine is less reinforcing at lower doses in aged male, but not female rats. This research has potential clinical implications for the chronic treatments involving opioids in aged individuals.
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