Programmed death 1 regulates development of central memory CD8 T cells after acute viral infection.
Programmed death 1 regulates development of central memory CD8 T cells after acute viral infection.
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DOI：
10.4049/jimmunol.1003870
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发表时间：
2011-06-01
期刊：
影响因子：
--
通讯作者：
Usherwood EJ
中科院分区：
文献类型：
--
作者：
Allie SR;Zhang W;Fuse S;Usherwood EJ
T细胞应答具有许多抑制性受体以调节抗病毒应答的程度并防止免疫病理学。这些受体通常在效应器反应期间瞬时上调，然后在记忆期间下调。一些抑制性受体，如程序性死亡1（PD-1）和LAG-3，显示在慢性淋巴细胞性脉络丛脑膜炎病毒感染的记忆过程中异常上调，限制了功能能力。然而，很少有人知道抑制性受体对记忆发展的影响，在正常的CD 8 T细胞对急性病毒感染的反应。我们以前的数据表明，PD-1在次级应答期间通过记忆CD 8 T细胞异常上调，这些记忆CD 8 T细胞在没有CD 4 T细胞帮助的情况下产生。因此，我们研究了PD-1在完整小鼠急性牛痘病毒感染期间记忆分化中的作用。在不存在PD-1的情况下，初级和记忆性CD 8 T细胞应答增强。此外，记忆PD-1−/− CD 8 T细胞中存在明显的表型和功能变化。检测到更高水平的CD 62 L、CD 27和CCR 7;细胞产生更多的IL-2并产生增强的次级应答。这些变化表明在不存在PD-1信号传导的情况下，记忆群体向中央记忆表型倾斜。
The T cell response possesses a number of inhibitory receptors to regulate the extent of the antiviral response and prevent immune pathology. These receptors are generally transiently upregulated during an effector response and then downregulated during memory. Some inhibitory receptors, such as programmed death 1 (PD-1) and LAG-3, were shown to be aberrantly upregulated during memory to chronic lymphocytic choriomeningitis virus infection, limiting functional capabilities. However, little is known about the impact of inhibitory receptors on memory development during a normal CD8 T cell response to acute virus infection. Our previous data showed that PD-1 is aberrantly upregulated during a secondary response by memory CD8 T cells that were generated without CD4 T cell help. Therefore, we examined the role of PD-1 in memory differentiation during acute vaccinia virus infection in intact mice. In the absence of PD-1, the primary and memory CD8 T cell responses were enhanced. Moreover, there were distinct phenotypic and functional changes in the memory PD-1−/− CD8 T cells. Higher levels of CD62L, CD27, and CCR7 were detected; cells produced more IL-2 and made an enhanced secondary response. These changes indicate a skewing of the memory population toward the central memory phenotype in the absence of PD-1 signaling.
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DOI：
10.4049/jimmunol.0802041
发表时间：
2009-04-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Fuse S;Tsai CY;Molloy MJ;Allie SR;Zhang W;Yagita H;Usherwood EJ
通讯作者：
Usherwood EJ
影响因子：
6.7
作者：
Sehrawat S;Reddy PB;Rajasagi N;Suryawanshi A;Hirashima M;Rouse BT
通讯作者：
Rouse BT
影响因子：
5.4
作者：
Urbani, Simona;Amadei, Barbara;Ferrari, Carlo
通讯作者：
Ferrari, Carlo
DOI：
10.1073/pnas.0809422106
发表时间：
2009-04-14
影响因子：
11.1
作者：
Huang, Xin;Venet, Fabienne;Ayala, Alfred
通讯作者：
Ayala, Alfred
影响因子：
3.5
作者：
Sheppard, KA;Fitz, LJ;Chaudhary, D
通讯作者：
Chaudhary, D