Flexible neural control of motor units.
Flexible neural control of motor units.
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DOI：
10.1038/s41593-022-01165-8
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发表时间：
2022-11
影响因子：
25
通讯作者：
Churchland, Mark M.
中科院分区：
文献类型：
--
作者：
Marshall, Najja J.;Glaser, Joshua, I;Trautmann, Eric M.;Amematsro, Elom A.;Perkins, Sean M.;Shadlen, Michael N.;Abbott, L. F.;Cunningham, John P.;Churchland, Mark M.
自主运动需要从皮层到脊髓的通信，脊髓中有一个专门的运动单位（MU）池激活每块肌肉。MU函数的规范描述依赖于两个基本原则。首先，皮层不能独立地控制MU，而是为每个池提供公共驱动器。其次，MU的招募方式严格，这在很大程度上符合亨尼曼的规模原则。虽然这种模式有相当多的经验支持，直接测试需要同时观察许多MU在不同的力剖面。我们开发了一个等距任务，允许稳定的MU记录，在恒河猴，即使在快速变化的力量。MU活动的模式是令人惊讶的行为依赖，可以准确地描述只有通过假设多个驱动器。与灵活的下行控制一致，微刺激相邻的皮质部位招募不同的MUs.Further，皮质人口的反应显示出足够的自由度，潜在地施加细粒度的控制。因此，MU活动是灵活控制，以满足任务的要求和皮层可能有助于这种能力。
Voluntary movement requires communication from cortex to the spinal cord, where a dedicated pool of motor units (MUs) activates each muscle. The canonical description of MU function rests upon two foundational tenets. First, cortex cannot control MUs independently but supplies each pool with a common drive. Second, MUs are recruited in a rigid fashion that largely accords with Henneman’s size principle. While this paradigm has considerable empirical support, a direct test requires simultaneous observations of many MUs across diverse force profiles. We developed an isometric task that allowed stable MU recordings, in a rhesus macaque, even during rapidly changing forces. Patterns of MU activity were surprisingly behavior-dependent and could be accurately described only by assuming multiple drives. Consistent with flexible descending control, microstimulation of neighboring cortical sites recruited different MUs. Furthermore, the cortical population response displayed sufficient degrees of freedom to potentially exert fine-grained control. Thus, MU activity is flexibly controlled to meet task demands and cortex may contribute to this ability.
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影响因子：
4
作者：
Formento, Emanuele;Botros, Paul;Carmena, Jose M.
通讯作者：
Carmena, Jose M.
DOI：
10.1111/j.1748-1716.1970.tb04744.x
发表时间：
1970-01-01
期刊：
ACTA PHYSIOLOGICA SCANDINAVICA
影响因子：
--
作者：
BUCHTHAL, F;SCHMALBR.H
通讯作者：
SCHMALBR.H
影响因子：
2.5
作者：
Feeney, Daniel F.;Meyer, Francois G.;Enoka, Roger M.
通讯作者：
Enoka, Roger M.
影响因子：
16.2
作者：
Chung JE;Magland JF;Barnett AH;Tolosa VM;Tooker AC;Lee KY;Shah KG;Felix SH;Frank LM;Greengard LF
通讯作者：
Greengard LF
影响因子：
5.5
作者：
DESMEDT, JE;GODAUX, E
通讯作者：
GODAUX, E