Developmental neurotoxicants in e-waste: an emerging health concern.
Developmental neurotoxicants in e-waste: an emerging health concern.
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DOI：
10.1289/ehp.1002452
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发表时间：
2011-04
影响因子：
10.4
通讯作者：
Ho SM
中科院分区：
文献类型：
--
作者：
Chen A;Dietrich KN;Huo X;Ho SM
电子废物在发达国家和发展中国家都是一个新出现的环境健康问题，但其目前的管理做法可能会导致弱势群体意外的发育神经毒性。为了提供关于问题范围、已知和疑似神经毒物的存在、毒理学机制和当前数据缺口的最新信息，我们进行了本次文献综述。我们回顾了PubMed和Web of Science中关于电子废物毒物及其潜在发育神经毒性的原始文章和综述论文。我们还检索了政府间和政府机构以及非政府组织关于电子废物生产和管理实践的已发表报告。我们关注的是弱势群体（即孕妇和发育中的儿童）对电子废物有毒物质的潜在暴露以及神经发育结果。此外，我们总结了发育神经毒性和机制的实验证据。在大多数非正式和原始电子废物回收的发展中国家，孕妇和幼儿普遍接触铅、镉、铬、多溴二苯醚、多氯联苯和多环芳烃，浓度很高。发育神经毒性在这些地区是一个严重的问题，但人类研究的不利影响和潜在的机制是稀缺的。重金属和持久性有机污染物前所未有的混合暴露值得进一步研究，并需要采取有效的污染控制措施。生活在非正规电子垃圾回收站附近的孕妇和幼儿有可能受到胎儿和儿童神经发育的干扰。
Electronic waste (e-waste) has been an emerging environmental health issue in both developed and developing countries, but its current management practice may result in unintended developmental neurotoxicity in vulnerable populations. To provide updated information about the scope of the issue, presence of known and suspected neurotoxicants, toxicologic mechanisms, and current data gaps, we conducted this literature review. We reviewed original articles and review papers in PubMed and Web of Science regarding e-waste toxicants and their potential developmental neurotoxicity. We also searched published reports of intergovernmental and governmental agencies and nongovernmental organizations on e-waste production and management practice. We focused on the potential exposure to e-waste toxicants in vulnerable populations—that is, pregnant women and developing children—and neurodevelopmental outcomes. In addition, we summarize experimental evidence of developmental neurotoxicity and mechanisms. In developing countries where most informal and primitive e-waste recycling occurs, environmental exposure to lead, cadmium, chromium, polybrominated diphenyl ethers, polychlorinated biphenyls, and polycyclic aromatic hydrocarbons is prevalent at high concentrations in pregnant women and young children. Developmental neurotoxicity is a serious concern in these regions, but human studies of adverse effects and potential mechanisms are scarce. The unprecedented mixture of exposure to heavy metals and persistent organic pollutants warrants further studies and necessitates effective pollution control measures. Pregnant women and young children living close to informal e-waste recycling sites are at risk of possible perturbations of fetus and child neurodevelopment.
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影响因子：
3.4
作者：
Cao Y;Chen A;Jones RL;Radcliffe J;Caldwell KL;Dietrich KN;Rogan WJ
通讯作者：
Rogan WJ
影响因子：
3.4
作者：
Brubaker CJ;Schmithorst VJ;Haynes EN;Dietrich KN;Egelhoff JC;Lindquist DM;Lanphear BP;Cecil KM
通讯作者：
Cecil KM
影响因子：
10.4
作者：
Benbrahim-Tallaa L;Waterland RA;Dill AL;Webber MM;Waalkes MP
通讯作者：
Waalkes MP
影响因子：
3.6
作者：
Baccarelli A;Bollati V
通讯作者：
Bollati V
影响因子：
120.7
作者：
DeRouen, TA;Martin, MD;Martins, IP
通讯作者：
Martins, IP