Seasonal and daytime variation in multiple immune parameters in humans: Evidence from 329,261 participants of the UK Biobank cohort.
Seasonal and daytime variation in multiple immune parameters in humans: Evidence from 329,261 participants of the UK Biobank cohort.
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DOI：
10.1016/j.isci.2021.102255
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发表时间：
2021-04-23
期刊：
影响因子：
5.8
通讯作者：
Smith DJ
中科院分区：
文献类型：
--
作者：
Wyse C;O'Malley G;Coogan AN;McConkey S;Smith DJ
季节性疾病暴发是人类传染病的长期特征，但产生这些模式的因素尚不清楚。在这里，我们调查了英国生物银行329261名参与者的多种免疫参数的季节性和日间变化，并测试了与广泛的环境和生活方式因素的关系，包括收集血液样本时白天长度、室外温度和维生素D的变化。季节模式在淋巴细胞、中性粒细胞计数和c反应蛋白CRP中很明显，但单核细胞不明显，这些与生活方式、人口统计学和环境因素无关。所有评估的免疫参数都显示出与混杂因素无关的显著的日间变化。在人群水平上，人类免疫参数随季节和一天中的不同时间而变化，独立于多种混杂因素。季节和时间都是免疫功能的基本维度，在所有免疫预防和疾病传播的研究中都应该考虑到这一点。季节性暴发是人类传染病的共同特征，在英国生物库参与者中，免疫参数随季节和时间的变化而变化，免疫参数的先天变异可能影响人类对疾病的易感性。免疫反应;生物钟学
Seasonal disease outbreaks are perennial features of human infectious disease but the factors generating these patterns are unclear. Here we investigate seasonal and daytime variability in multiple immune parameters in 329,261 participants in UK Biobank and test for associations with a wide range of environmental and lifestyle factors, including changes in day length, outdoor temperature and vitamin D at the time the blood sample was collected. Seasonal patterns were evident in lymphocyte and neutrophil counts, and C-reactive protein CRP, but not monocytes, and these were independent of lifestyle, demographic, and environmental factors. All the immune parameters assessed demonstrated significant daytime variation that was independent of confounding factors. At a population level, human immune parameters vary across season and across time of day, independent of multiple confounding factors. Both season and time of day are fundamental dimensions of immune function that should be considered in all studies of immuno-prophylaxis and disease transmission. Seasonal outbreaks are common features of human infectious disease Immune parameters varied across seasons and time of day in UK Biobank participants Innate variability in immune parameters could influence human susceptibility to disease Immunology; Immune Response; Chronobiology
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淋巴细胞昼夜节律的时钟控制淋巴结运输和适应性免疫反应。
影响因子：
32.4
作者：
Druzd D;Matveeva O;Ince L;Harrison U;He W;Schmal C;Herzel H;Tsang AH;Kawakami N;Leliavski A;Uhl O;Yao L;Sander LE;Chen CS;Kraus K;de Juan A;Hergenhan SM;Ehlers M;Koletzko B;Haas R;Solbach W;Oster H;Scheiermann C
通讯作者：
Scheiermann C
影响因子：
3.7
作者：
Alamili M;Bendtzen K;Lykkesfeldt J;Rosenberg J;Gögenur I
通讯作者：
Gögenur I
影响因子：
3.7
作者：
Bloom-Feshbach K;Alonso WJ;Charu V;Tamerius J;Simonsen L;Miller MA;Viboud C
通讯作者：
Viboud C
影响因子：
32.4
作者：
Adrover, Jose M.;del Fresno, Carlos;Hidalgo, Andres
通讯作者：
Hidalgo, Andres
DOI：
10.1073/pnas.1601895113
发表时间：
2016-09-06
影响因子：
11.1
作者：
Edgar, Rachel S.;Stangherlin, Alessandra;Reddy, Akhilesh B.
通讯作者：
Reddy, Akhilesh B.