Heart rate and risk of cancer death in healthy men.
Heart rate and risk of cancer death in healthy men.
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DOI：
10.1371/journal.pone.0021310
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发表时间：
2011
期刊：
影响因子：
3.7
通讯作者：
Ducimetière P
中科院分区：
文献类型：
--
作者：
Jouven X;Escolano S;Celermajer D;Empana JP;Bingham A;Hermine O;Desnos M;Perier MC;Marijon E;Ducimetière P
先前几项研究心率和心血管风险的数据暗示心率和非心源性死亡率之间可能存在关系。因此，我们系统地研究了心率变量对随后癌症死亡风险的预测价值。在巴黎前瞻性研究I中，6101名年龄在42至53岁之间的无症状法国工人，无临床可检测的心血管疾病和癌症，在1967年至1972年期间接受了标准化分级运动试验。测量静息心率、运动时心率增加和恢复时心率降低。在5139名男性中，也可获得5年内静息心率的变化。在25年的随访中，对包括758例癌症死亡在内的死亡率进行了评估。所有心率参数与随后的癌症死亡之间存在强烈的、分级的和显著的关系。校正年龄和烟草消费后，与最低四分位数相比，静息心率最高四分位数的人癌症死亡的相对危险度为2.4（95%置信区间：1.9-2.9，p<0.0001），校正传统心血管危险因素后相似，并观察到最常见的恶性肿瘤（呼吸道和胃肠道）。同样，在运动期间心率增加不佳、恢复期间心率下降不佳和随着时间的推移心率增加更大之间观察到与癌症死亡的显著关系（所有p<0.0001）。静息和运动心率与男性随后的癌症死亡率具有一致的、分级的和高度显著的相关性。
Data from several previous studies examining heart-rate and cardiovascular risk have hinted at a possible relationship between heart-rate and non-cardiac mortality. We thus systematically examined the predictive value of heart-rate variables on the subsequent risk of death from cancer. In the Paris Prospective Study I, 6101 asymptomatic French working men aged 42 to 53 years, free of clinically detectable cardiovascular disease and cancer, underwent a standardized graded exercise test between 1967 and 1972. Resting heart-rate, heart-rate increase during exercise, and decrease during recovery were measured. Change in resting heart-rate over 5 years was also available in 5139 men. Mortality including 758 cancer deaths was assessed over the 25 years of follow-up. There were strong, graded and significant relationships between all heart-rate parameters and subsequent cancer deaths. After adjustment for age and tobacco consumption and, compared with the lowest quartile, those with the highest quartile for resting heart-rate had a relative risk of 2.4 for cancer deaths (95% confidence interval: 1.9–2.9, p<0.0001) This was similar after adjustment for traditional cardiovascular risk factors and was observed for the commonest malignancies (respiratory and gastrointestinal). Similarly, significant relationships with cancer death were observed between poor heart rate increase during exercise, poor decrease during recovery and greater heart-rate increase over time (p<0.0001 for all). Resting and exercise heart rate had consistent, graded and highly significant associations with subsequent cancer mortality in men.
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影响因子：
24
作者：
Fox, Kim;Borer, Jeffrey S.;Tendera, Michal
通讯作者：
Tendera, Michal
影响因子：
39.3
作者：
Jouven, Xavier;Schwartz, Peter J.;Ducimetiere, Pierre
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Ducimetiere, Pierre
影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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