Reproductive Aging in Caenorhabditis elegans: From Molecules to Ecology.
Reproductive Aging in Caenorhabditis elegans: From Molecules to Ecology.
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DOI：
10.3389/fcell.2021.718522
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发表时间：
2021
影响因子：
5.5
通讯作者：
Kornfeld K
中科院分区：
文献类型：
--
作者：
Scharf A;Pohl F;Egan BM;Kocsisova Z;Kornfeld K
衰老的动物表现出广泛的进行性退行性变化，其中最令人着迷的是女性生殖功能的下降。在模式生物秀丽隐杆线虫中，雌雄同体在成虫的第2天达到子代产量的高峰，然后迅速下降；后代的繁殖通常在成年后的第8天结束。由于动物通常存活到成年的第15天，因此有相当长的生殖后寿命。在这里，我们回顾了生殖衰老过程中发生的分子和细胞变化，包括干细胞数量和活性的减少，减数分裂进程的减慢，Notch信号的减弱以及种系和卵母细胞形态的恶化。已经确定了几种延缓生殖衰老的干预措施，包括突变、药物和温度等环境因素。生殖衰老的详细描述以及延缓这一过程的干预措施使秀丽隐杆线虫成为了解驱动生殖衰老机制的主要模型系统。虽然生殖老龄化对个人生育能力产生了巨大影响，但它也对人口生态产生了影响。人口动态是由出生和死亡驱动的，而生殖老龄化是影响出生率的一个重要因素。人们提出了各种各样的理论来解释生殖衰老发生的原因以及它在进化过程中是如何形成的。本文总结了这些理论，并讨论了秀丽隐杆线虫在测试生殖衰老机制和进化模型中的应用。
Aging animals display a broad range of progressive degenerative changes, and one of the most fascinating is the decline of female reproductive function. In the model organism Caenorhabditis elegans, hermaphrodites reach a peak of progeny production on day 2 of adulthood and then display a rapid decline; progeny production typically ends by day 8 of adulthood. Since animals typically survive until day 15 of adulthood, there is a substantial post reproductive lifespan. Here we review the molecular and cellular changes that occur during reproductive aging, including reductions in stem cell number and activity, slowing meiotic progression, diminished Notch signaling, and deterioration of germ line and oocyte morphology. Several interventions have been identified that delay reproductive aging, including mutations, drugs and environmental factors such as temperature. The detailed description of reproductive aging coupled with interventions that delay this process have made C. elegans a leading model system to understand the mechanisms that drive reproductive aging. While reproductive aging has dramatic consequences for individual fertility, it also has consequences for the ecology of the population. Population dynamics are driven by birth and death, and reproductive aging is one important factor that influences birth rate. A variety of theories have been advanced to explain why reproductive aging occurs and how it has been sculpted during evolution. Here we summarize these theories and discuss the utility of C. elegans for testing mechanistic and evolutionary models of reproductive aging.
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DOI：
10.18632/aging.100273
发表时间：
2011-02
期刊：
Aging
影响因子：
--
作者：
Anisimov VN;Berstein LM;Popovich IG;Zabezhinski MA;Egormin PA;Piskunova TS;Semenchenko AV;Tyndyk ML;Yurova MN;Kovalenko IG;Poroshina TE
通讯作者：
Poroshina TE
影响因子：
4.8
作者：
Feistel, Dorian J.;Elmostafa, Rema;Hickman, Meleah A.
通讯作者：
Hickman, Meleah A.
影响因子：
7.7
作者：
Booth, Lauren N.;Maures, Travis J.;Brunet, Anne
通讯作者：
Brunet, Anne
影响因子：
7.8
作者：
Achache H;Falk R;Lerner N;Beatus T;Tzur YB
通讯作者：
Tzur YB
影响因子：
3.3
作者：
Corsi AK;Wightman B;Chalfie M
通讯作者：
Chalfie M