Molecular Modulation of Fetal Liver Hematopoietic Stem Cell Mobilization into Fetal Bone Marrow in Mice.
Molecular Modulation of Fetal Liver Hematopoietic Stem Cell Mobilization into Fetal Bone Marrow in Mice.
复制标题
小鼠胎儿肝脏造血干细胞动员至胎儿骨髓的分子调节
DOI：
10.1155/2020/8885154
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发表时间：
2020
影响因子：
4.3
通讯作者：
Shao L
中科院分区：
文献类型：
--
作者：
Zeng H;Cheng J;Fan Y;Luan Y;Yang J;Wang F;Yang S;Shao L
造血干细胞的发育是一个复杂的过程，已经得到了广泛的研究。小鼠胎肝中的造血干细胞(HSCs)被高度扩增，为将HSCs动员到胎儿骨髓中做准备。目前尚不完全清楚胎肝生态位如何在不丧失自我更新能力的情况下调节HSC的扩张。我们综述了胎儿肝巢、趋化因子、细胞因子和信号通路对HSC自我更新、增殖和扩增的影响的最新进展。我们讨论了胚胎HSC在小鼠和斑马鱼体内扩增的分子调控。来自胎肝的HSCs是如何动员、循环和驻留在胎儿骨髓穴中的，也是未知的。我们综述了外在因素和内在因素如何调节胎肝HSC向胎儿骨髓的动员，为提高HSC在HSC移植中的植入效率提供了工具。了解胎肝HSC向胎儿骨髓动员的规律，有助于我们为妊娠期白血病等疾病的治疗设计合适的临床治疗方案。我们展望胎儿细胞，包括肝细胞、内皮细胞和造血细胞，可能调节胎肝HSC的扩增。血管内皮细胞和骨骼中的成分也可能调节胎肝HSCs进入骨髓。本综述对深入了解哺乳动物胎肝和骨髓中HSCs的分子调控具有很大的潜力，这将有助于HSCs的体外高效扩增。
Development of hematopoietic stem cells is a complex process, which has been extensively investigated. Hematopoietic stem cells (HSCs) in mouse fetal liver are highly expanded to prepare for mobilization of HSCs into the fetal bone marrow. It is not completely known how the fetal liver niche regulates HSC expansion without loss of self-renewal ability. We reviewed current progress about the effects of fetal liver niche, chemokine, cytokine, and signaling pathways on HSC self-renewal, proliferation, and expansion. We discussed the molecular regulations of fetal HSC expansion in mouse and zebrafish. It is also unknown how HSCs from the fetal liver mobilize, circulate, and reside into the fetal bone marrow niche. We reviewed how extrinsic and intrinsic factors regulate mobilization of fetal liver HSCs into the fetal bone marrow, which provides tools to improve HSC engraftment efficiency during HSC transplantation. Understanding the regulation of fetal liver HSC mobilization into the fetal bone marrow will help us to design proper clinical therapeutic protocol for disease treatment like leukemia during pregnancy. We prospect that fetal cells, including hepatocytes and endothelial and hematopoietic cells, might regulate fetal liver HSC expansion. Components from vascular endothelial cells and bones might also modulate the lodging of fetal liver HSCs into the bone marrow. The current review holds great potential to deeply understand the molecular regulations of HSCs in the fetal liver and bone marrow in mammals, which will be helpful to efficiently expand HSCs in vitro.
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影响因子：
7.7
作者：
Azzoni E;Frontera V;McGrath KE;Harman J;Carrelha J;Nerlov C;Palis J;Jacobsen SEW;de Bruijn MF
通讯作者：
de Bruijn MF
肌动蛋白调节波复合物的结构和控制。
影响因子：
64.8
作者：
Chen, Zhucheng;Borek, Dominika;Padrick, Shae B.;Gomez, Timothy S.;Metlagel, Zoltan;Ismail, Ayman M.;Umetani, Junko;Billadeau, Daniel D.;Otwinowski, Zbyszek;Rosen, Michael K.
通讯作者：
Rosen, Michael K.
影响因子：
3.7
作者：
Ciriza J;Hall D;Lu A;De Sena JR;Al-Kuhlani M;García-Ojeda ME
通讯作者：
García-Ojeda ME
影响因子：
2.5
作者：
Alva, JA;Zovein, AC;Iruela-Arispe, ML
通讯作者：
Iruela-Arispe, ML
影响因子：
20.3
作者：
Chen, Yu;Haviernik, Peter;Yang, Yu-Chung
通讯作者：
Yang, Yu-Chung