Integrated mutation, copy number and expression profiling in resectable non-small cell lung cancer.
Integrated mutation, copy number and expression profiling in resectable non-small cell lung cancer.
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DOI：
10.1186/1471-2407-11-93
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发表时间：
2011-03-07
期刊：
影响因子：
3.8
通讯作者：
Thomas DM
中科院分区：
文献类型：
--
作者：
Newnham GM;Conron M;McLachlan S;Dobrovic A;Do H;Li J;Opeskin K;Thompson N;Wright GM;Thomas DM
本研究的目的是确定参与非小细胞肺癌（NSCLC）发病机制的关键基因，从而更全面地了解这种疾病，并确定新的分子靶点，用于开发更有效的治疗方法。对69例切除的NSCLC标本进行转录和基因组谱分析，并将结果与突变分析和临床数据相关联，以确定与感兴趣群体相关的遗传改变。联合分析确定了与腺癌和鳞状分化相关的特定遗传改变模式；KRAS突变;TP53突变、转移潜能和疾病复发及生存。3q扩增与腺癌TP53突变相关。反映KRAS通路激活的疾病复发预后标志在一个独立的测试集中得到验证。这些结果可能为确定新的预测性生物标志物和新疗法的靶点提供了第一步，从而改善了这种致命疾病患者的预后。
The aim of this study was to identify critical genes involved in non-small cell lung cancer (NSCLC) pathogenesis that may lead to a more complete understanding of this disease and identify novel molecular targets for use in the development of more effective therapies. Both transcriptional and genomic profiling were performed on 69 resected NSCLC specimens and results correlated with mutational analyses and clinical data to identify genetic alterations associated with groups of interest. Combined analyses identified specific patterns of genetic alteration associated with adenocarcinoma vs. squamous differentiation; KRAS mutation; TP53 mutation, metastatic potential and disease recurrence and survival. Amplification of 3q was associated with mutations in TP53 in adenocarcinoma. A prognostic signature for disease recurrence, reflecting KRAS pathway activation, was validated in an independent test set. These results may provide the first steps in identifying new predictive biomarkers and targets for novel therapies, thus improving outcomes for patients with this deadly disease.
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影响因子：
11.2
作者：
DeYoung, Maurice Phillip;Johannessen, Cory M.;Ellisen, Leif W.
通讯作者：
Ellisen, Leif W.
高分辨率熔化用于TP53外显子5-8的突变扫描。
影响因子：
3.8
作者：
Krypuy, Michael;Ahmed, Ahmed Ashour;Etemadmoghadam, Dariush;Hyland, Sarah J.;deFazio, Anna;Fox, Stephen B.;Brenton, James D.;Bowtell, David D.;Dobrovic, Alexander
通讯作者：
Dobrovic, Alexander
影响因子：
3.8
作者：
Krypuy M;Newnham GM;Thomas DM;Conron M;Dobrovic A
通讯作者：
Dobrovic A
影响因子：
5.3
作者：
Kasprzyk, M;Dyszkiewicz, W;Kaczmarek, E
通讯作者：
Kaczmarek, E
影响因子：
2.1
作者：
Olshen, AB;Venkatraman, ES;Wigler, M
通讯作者：
Wigler, M