Nasopharyngeal Lactobacillus is associated with a reduced risk of childhood wheezing illnesses following acute respiratory syncytial virus infection in infancy.
Nasopharyngeal Lactobacillus is associated with a reduced risk of childhood wheezing illnesses following acute respiratory syncytial virus infection in infancy.
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DOI：
10.1016/j.jaci.2017.10.049
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发表时间：
2018-11
期刊：
影响因子：
--
通讯作者：
Hartert TV
中科院分区：
文献类型：
--
作者：
Rosas-Salazar C;Shilts MH;Tovchigrechko A;Schobel S;Chappell JD;Larkin EK;Gebretsadik T;Halpin RA;Nelson KE;Moore ML;Anderson LJ;Peebles RS Jr;Das SR;Hartert TV
早期呼吸道合胞病毒（RSV）急性呼吸道感染（ARI）与儿童喘息性疾病的发生密切相关，但这种相关性的潜在途径尚不清楚。研究鼻咽微生物组在婴儿期RSV ARI后儿童喘息性疾病发生中的作用。我们对118名先前健康的足月婴儿进行了巢式队列研究，这些婴儿通过RT-PCR确诊为RSV ARI。我们使用16 S核糖体RNA基因V4区的下一代测序来表征RSVARI期间的鼻咽微生物组。我们关注的主要结果是2年后的喘息。在118名婴儿中，113名（95.8%）有2年的结局数据。其中，46例（40.7%）有父母报告随后的喘息。RSV ARI期间鼻咽微生物组的总体分类组成、多样性和丰富性与随后喘息的发生之间没有关联。然而，在没有出现这种结果的婴儿中，鼻咽部乳酸杆菌的检测和丰度始终较高。在一个区分有和没有随后喘息的婴儿的模型中，乳酸菌也在不同属中排名第一。婴儿期RSV ARI期间鼻咽部检测和乳酸杆菌丰度增加与2岁时儿童喘息性疾病风险降低相关。
Early life acute respiratory infection (ARI) with respiratory syncytial virus (RSV) has been strongly associated with the development of childhood wheezing illnesses, but the pathways underlying this association are poorly understood. To examine the role of the nasopharyngeal microbiome in the development of childhood wheezing illnesses following RSV ARI in infancy. We conducted a nested cohort study of 118 previously healthy, term infants with confirmed RSV ARI by RT-PCR. We used next-generation sequencing of the V4 region of the 16S ribosomal RNA gene to characterize the nasopharyngeal microbiome during RSVARI. Our main outcome of interest was 2-year subsequent wheeze. Of the 118 infants, 113 (95.8%) had 2-year outcome data. Of these, 46 (40.7%) had parental report of subsequent wheeze. There was no association between the overall taxonomic composition, diversity, and richness of the nasopharyngeal microbiome during RSV ARI with the development of subsequent wheeze. However, the nasopharyngeal detection and abundance of Lactobacillus was consistently higher in infants who did not develop this outcome. Lactobacillus also ranked first among the different genera in a model distinguishing infants with and without subsequent wheeze. The nasopharyngeal detection and increased abundance of Lactobacillus during RSV ARI in infancy are associated with a reduced risk of childhood wheezing illnesses at age 2 years.
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影响因子：
7.3
作者：
Kitazawa H;Villena J
通讯作者：
Villena J
DOI：
10.1164/rccm.201405-0901pp
发表时间：
2015-01-01
影响因子：
24.7
作者：
Feldman, Amy S.;He, Yuan;Hartert, Tina V.
通讯作者：
Hartert, Tina V.
DOI：
10.1056/nejmoa0804877
发表时间：
2009-02-05
期刊：
The New England journal of medicine
影响因子：
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作者：
Hall CB;Weinberg GA;Iwane MK;Blumkin AK;Edwards KM;Staat MA;Auinger P;Griffin MR;Poehling KA;Erdman D;Grijalva CG;Zhu Y;Szilagyi P
通讯作者：
Szilagyi P
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y
影响因子：
3
作者：
Hofner B;Boccuto L;Göker M
通讯作者：
Göker M