Modulation of Respiratory TLR3-Anti-Viral Response by Probiotic Microorganisms: Lessons Learned from Lactobacillus rhamnosus CRL1505.
Modulation of Respiratory TLR3-Anti-Viral Response by Probiotic Microorganisms: Lessons Learned from Lactobacillus rhamnosus CRL1505.
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DOI：
10.3389/fimmu.2014.00201
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发表时间：
2014
影响因子：
7.3
通讯作者：
Villena J
中科院分区：
文献类型：
--
作者：
Kitazawa H;Villena J
呼吸道合胞病毒（RSV）是婴幼儿下呼吸道疾病的主要原因。宿主免疫应答涉及RSV感染期间的保护性和免疫病理学机制。RSV激活天然免疫细胞中的Toll样受体（TLR）-3可诱导气道炎症、保护性免疫应答和肺免疫病理学。清楚地了解RSV-宿主相互作用对于开发新的有效的治疗策略是重要的。一些研究集中在具有刺激免疫系统能力的益生菌微生物（免疫生物制剂）是否可以充分刺激常见的粘膜免疫系统，以改善呼吸道的防御。在这方面，已经证明一些口服免疫生物剂确实具有刺激呼吸道免疫和增加对病毒感染的抵抗力的能力。此外，在过去的十年中，科学家们在呼吸道免疫生物素保护作用所涉及的细胞和分子机制的知识方面取得了显着进展。本文综述了使用免疫生物素细菌提高对病毒性呼吸道感染的抵抗力的最新进展。更具体地说，文章讨论了免疫生物素菌株鼠李糖乳杆菌CRL 1505调节呼吸道TLR 3介导的免疫应答和增加对RSV感染的抵抗力的能力所涉及的机制。此外，我们还回顾了干扰素（IFN）-γ和白细胞介素（IL）-10在CRL 1505菌株免疫调节作用中的作用，该菌株已成功用于降低儿童病毒性气道感染的发病率和发病率。
Respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract illness in infants and young children. Host immune response is implicated in both protective and immunopathological mechanisms during RSV infection. Activation of Toll-like receptor (TLR)-3 in innate immune cells by RSV can induce airway inflammation, protective immune response, and pulmonary immunopathology. A clear understanding of RSV–host interaction is important for the development of novel and effective therapeutic strategies. Several studies have centered on whether probiotic microorganisms with the capacity to stimulate the immune system (immunobiotics) might sufficiently stimulate the common mucosal immune system to improve defenses in the respiratory tract. In this regard, it was demonstrated that some orally administered immunobiotics do have the ability to stimulate respiratory immunity and increase resistance to viral infections. Moreover, during the last decade scientists have significantly advanced in the knowledge of the cellular and molecular mechanisms involved in the protective effect of immunobiotics in the respiratory tract. This review examines the most recent advances dealing with the use of immunobiotic bacteria to improve resistance against viral respiratory infections. More specifically, the article discuss the mechanisms involved in the capacity of the immunobiotic strain Lactobacillus rhamnosus CRL1505 to modulate the TLR3-mediated immune response in the respiratory tract and to increase the resistance to RSV infection. In addition, we review the role of interferon (IFN)-γ and interleukin (IL)-10 in the immunoregulatory effect of the CRL1505 strain that has been successfully used for reducing incidence and morbidity of viral airways infections in children.
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DOI：
10.1165/rcmb.2011-0070oc
发表时间：
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影响因子：
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