Differences in the dose-volume metrics with heterogeneity correction status and its influence on local control in stereotactic body radiation therapy for lung cancer.
Differences in the dose-volume metrics with heterogeneity correction status and its influence on local control in stereotactic body radiation therapy for lung cancer.
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DOI：
10.1093/jrr/rrs084
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发表时间：
2013-03-01
影响因子：
2
通讯作者：
Hiraoka M
中科院分区：
文献类型：
--
作者：
Ueki N;Matsuo Y;Shibuya K;Nakamura M;Narabayashi M;Sakanaka K;Norihisa Y;Mizowaki T;Hiraoka M
本研究的目的是评估不同异质性校正下的剂量-体积指标以及立体定向体部放射治疗（SBRT）治疗非小细胞肺癌（NSCLC）后局部复发（LR）的相关因素。回顾性分析了83例因病理证实的I期NSCLC接受SBRT的患者。处方剂量为48戈伊，在等中心（IC）的四个部分下的异质性校正与BPL（BPL）。在BPL和各向异性分析算法（AAA）下，使用Eclipse（Varian）对相同监测单元重新计算临床计划，无异质性校正（NC）。在每种算法下以及局部病变控制（LC）和LR患者之间，比较了IC处的剂量、覆盖95%体积的剂量（D95）、最小剂量（Min）和计划靶体积（PTV）的平均剂量（Mean）。NC下的IC剂量显著低于BPL和AAA下。在BPL下，平均PTV D95、Min和Mean分别比AAA下高8.0%、9.4%和7.4%，比NC下高9.6%、9.2%和4.6%。在AAA下，T1 a患者的所有剂量-体积参数均显著低于T1 b和T2 a患者。中位随访时间为35.9个月，18例患者发生LR。在LC和LR组之间，未观察到任何指标的显著差异。即使根据T分期分层后，LC和LR之间也没有观察到显著差异。
The purpose of this study is to evaluate the dose–volume metrics under different heterogeneity corrections and the factors associated with local recurrence (LR) after stereotactic body radiation therapy (SBRT) for non-small-cell lung cancer (NSCLC). Eighty-three patients who underwent SBRT for pathologically proven stage I NSCLC were reviewed retrospectively. The prescribed dose was 48 Gy in four fractions at the isocenter (IC) under heterogeneity correction with the Batho power law (BPL). The clinical plans were recalculated with Eclipse (Varian) for the same monitor units under the BPL and anisotropic analytical algorithm (AAA) and with no heterogeneity correction (NC). The dose at the IC, dose that covers 95% of the volume (D95), minimum dose (Min), and mean dose (Mean) of the planning target volume (PTV) were compared under each algorithm and between patients with local lesion control (LC) and LR. The IC doses under NC were significantly lower than those under the BPL and AAA. Under the BPL, the mean PTV D95, Min and Mean were 8.0, 9.4 and 7.4% higher than those under the AAA, and 9.6, 9.2 and 4.6% higher than those under NC, respectively. Under the AAA, all dose–volumetric parameters were significantly lower in T1a patients than in those with T1b and T2a. With a median follow-up of 35.9 months, LR occurred in 18 patients. Between the LC and LR groups, no significant differences were observed for any of the metrics. Even after stratification according to T-stage, no significant difference was observed between LC and LR.
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DOI：
10.1016/j.ijrobp.2008.11.019
发表时间：
2009-03-15
影响因子：
7
作者：
Xiao, Ying;Papiez, Lech;Paulus, Rebecca;Timmerman, Robert;Straube, William L.;Bosch, Wailter R.;Michalski, Jeff;Galvin, James M.
通讯作者：
Galvin, James M.
影响因子：
5.3
作者：
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通讯作者：
Ragona, Riccardo
影响因子：
3.1
作者：
BLOMGREN, H;LAX, I;SVANSTROM, R
通讯作者：
SVANSTROM, R
DOI：
10.1016/j.ijrobp.2010.02.012
发表时间：
2010-12-01
影响因子：
7
作者：
Galerani, Ana Paula;Grills, Inga;Yan, Di
通讯作者：
Yan, Di
影响因子：
3.1
作者：
Ronde, Heidi S.;Hoffmann, Lone
通讯作者：
Hoffmann, Lone