In Vivo Absolute Metabolite Quantification Using a Multiplexed ERETIC-RX Array Coil for Whole-Brain MR Spectroscopic Imaging.
In Vivo Absolute Metabolite Quantification Using a Multiplexed ERETIC-RX Array Coil for Whole-Brain MR Spectroscopic Imaging.
复制标题
使用多路复用ERETIC-RX阵列线圈进行全脑MR光谱成像的体内绝对代谢物定量。
DOI：
10.1002/jmri.28028
复制
发表时间：
2022-07
影响因子：
4.4
通讯作者：
Andronesi, Ovidiu C.
中科院分区：
文献类型：
--
作者：
Thapa, Bijaya;Mareyam, Azma;Stockmann, Jason;Strasser, Bernhard;Keil, Boris;Hoecht, Philipp;Carp, Stefan;Li, Xianqi;Wang, Zhe;Chang, Yulin, V;Dietrich, Jorg;Uhlmann, Erik;Cahill, Daniel P.;Batchelor, Tracy;Wald, Lawrence;Andronesi, Ovidiu C.
关键词：
在MR光谱成像（MRSI）中代谢物的绝对定量需要已知浓度的稳定参考信号。电子参考获取体内浓度（ERETIC）已显示出巨大的前景，但尚未应用于患者和3D MRSI。由于技术挑战，例如线圈组合和多个ERETIC和接收通道之间的不必要耦合，我们开发了缓解策略，因此ERETIC硬件尚未与接收阵列集成。建立脑胶质瘤患者全脑MRSI的绝对定量方法。有前途。5名健康志愿者和3名异柠檬酸脱氢酶突变型胶质瘤患者（27%女性）。校准和线圈加载体模。A 3 T;具有实时运动校正的绝热自旋回波螺旋3D MRSI、液体衰减反转恢复（FLAIR）、梯度回波（GRE）、多回波磁化准备梯度回波快速采集（MEMPRAGE）。使用定制的4x-ERETIC/8x接收阵列线圈对五种脑代谢物（总N-乙酰天冬氨酸[NAA]/肌酸/胆碱、谷氨酰胺+谷氨酸、肌醇）和癌代谢物2-羟基戊二酸进行绝对定量。采用EREIC和内部水参比方法进行代谢物定量。ERETIC信号通过光学链路传输，用于校正弹簧圈负载。测量了ERETIC和接收通道之间的感应和辐射耦合。使用Bland-Altman（BA）分析和非参数Mann-Whitney检验比较了用于代谢物定量的ERETIC和内水方法。P < 0.05为有统计学意义。ERETIC可以集成在接收阵列中，电感耦合占主导地位（5-886倍）辐射耦合。下图显示了ERETIC信号与线圈负载的比例缩放。BA分析表明，健康志愿者中的一致性非常好（3.3% ± 1.6%），而神经胶质瘤中ERETIC和内部水定量的代谢物浓度之间存在较大差异（36.1% ± 3.8%）。我们的研究结果表明，ERETIC集成接收阵列和全脑MRSI脑代谢物定量是可行的。需要进一步验证以探索ERETIC在胶质瘤患者中提供更准确的代谢物浓度。2阶段1
Absolute quantification of metabolites in MR spectroscopic imaging (MRSI) requires a stable reference signal of known concentration. The Electronic REference To access In vivo Concentrations (ERETIC) has shown great promise but has not been applied in patients and 3D MRSI. ERETIC hardware has not been integrated with receive arrays due to technical challenges, such as coil combination and unwanted coupling between multiple ERETIC and receive channels, for which we developed mitigation strategies. To develop absolute quantification for whole-brain MRSI in glioma patients. Prospective. Five healthy volunteers and three patients with isocitrate dehydrogenase mutant glioma (27% female). Calibration and coil loading phantoms. A 3T; Adiabatic spin-echo spiral 3D MRSI with real-time motion correction, Fluid Attenuated Inversion Recovery (FLAIR), Gradient Recalled Echo (GRE), Multi-echo Magnetization Prepared Rapid Acquisition of Gradient Echo (MEMPRAGE). Absolute quantification was performed for five brain metabolites (total N-acetyl-aspartate [NAA]/creatine/choline, glutamine + glutamate, myoinositol) and the oncometabolite 2-hydroxyglutarate using a custom-built 4x-ERETIC/8x-receive array coil. Metabolite quantification was performed with both EREIC and internal water reference methods. ERETIC signal was transmitted via optical link and used to correct coil loading. Inductive and radiative coupling between ERETIC and receive channels were measured. ERETIC and internal water methods for metabolite quantification were compared using Bland–Altman (BA) analysis and the nonparametric Mann–Whitney test. P < 0.05 was considered statistically significant. ERETIC could be integrated in receive arrays and inductive coupling dominated (5–886 times) radiative coupling. Phantoms show proportional scaling of the ERETIC signal with coil loading. The BA analysis demonstrated very good agreement (3.3% ± 1.6%) in healthy volunteers, while there was a large difference (36.1% ± 3.8%) in glioma tumors between metabolite concentrations by ERETIC and internal water quantification. Our results indicate that ERETIC integrated with receive arrays and whole-brain MRSI is feasible for brain metabolites quantification. Further validation is required to probe that ERETIC provides more accurate metabolite concentration in glioma patients. 2 Stage 1
登录
查看更多内容
影响因子：
64.8
作者：
通讯作者：
--
影响因子：
16.6
作者：
Andronesi OC;Arrillaga-Romany IC;Ly KI;Bogner W;Ratai EM;Reitz K;Iafrate AJ;Dietrich J;Gerstner ER;Chi AS;Rosen BR;Wen PY;Cahill DP;Batchelor TT
通讯作者：
Batchelor TT
影响因子：
2.9
作者：
Heinzer-Schweizer, S.;De Zanche, N.;Boesiger, P.
通讯作者：
Boesiger, P.
影响因子：
3.3
作者：
Hoge, RD;Kwan, RKS;Pike, GB
通讯作者：
Pike, GB
影响因子：
3.3
作者：
BUCHLI, R;BOESIGER, P
通讯作者：
BOESIGER, P