Effects of extracellular ATP on surfactant secretion.
Effects of extracellular ATP on surfactant secretion.
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细胞外 ATP 对表面活性剂分泌的影响。
DOI：
10.1111/j.1749-6632.1990.tb37662.x
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发表时间：
1990
影响因子：
5.2
通讯作者：
Rice,WR
中科院分区：
文献类型：
--
作者：
Rice,WR
Pulmonary surfactant that contains ooth lipids and proteins is synthesized, stored as lamellar bodies, and secreted by alveolar type II cells." Surfactant maintains the stability of the alveolus, iisuring normal ventilation and gas exchange by the lungs Inability to synthesize and secrete surfactant leads to hypoxemia and hypoventilation in certain clinical conditions like respiratory distreSs syndrome of the premature neonate and adult respiratory distress syndrome. Although the type II cell of the lung is known to be responsible for synthesis and secretion of surfactant, the mechanisms regulating these processes are less well understood-Secretion of surfactant from alveolar type II cells is being actively studied in many laboratories and is known to be augmented by agents affecting cAMP levels (, 6. adrenoceptor agonists," cholera toxin,'and forskohn'), prostaglandins,'protein kmase C agonists (phorbol esters'), agents that mobilize cytosolic calcium (A23187" and ionomycin), and agents that alter cytoskeletal associations (cytoclialasins"), One of the most potent agonists for surfactant secretion identified to date is exogenous ATP, which results in a three-to sixfold stimulation of surfactant secretion in vitro."'In the present work, the punnoceptor regulating surfactant secretion is charactenzed and the possible second messenger systems involved in regulation of purnoceptormediated surfactat secretion are cl-scribed.
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表面活性剂分泌的调节机制。
DOI：
10.1016/s0925-4439(98)00070-2
发表时间：
1998
期刊：
Biochimica et biophysica acta
影响因子：
--
作者：
Mason,RJ;Voelker,DR
通讯作者：
Voelker,DR
影响因子：
--
作者：
PODGORSKI, A;GRADON, L
通讯作者：
GRADON, L
使用自动微量滴定板荧光计进行磷脂定量的酶荧光测定程序。
影响因子：
9.3
作者：
M. Nanjee;A. Gebre;N. Miller
通讯作者：
N. Miller
表面活性剂蛋白 A 对体外颗粒肺细胞表面活性剂分泌的影响。
DOI：
10.1152/ajplung.00271.2002
发表时间：
2003
期刊：
American journal of physiology. Lung cellular and molecular physiology
影响因子：
--
作者：
Bates,SandraR;Tao,Jian-Qin;Notarfrancesco,Kathleen;DeBolt,Kristine;Shuman,Henry;Fisher,AronB
通讯作者：
Fisher,AronB
DOI：
10.1152/ajplung.00074.2005
发表时间：
2005-09
期刊：
American journal of physiology. Lung cellular and molecular physiology
影响因子：
--
作者：
A. Patel;D. Reigada;C. Mitchell;S. Bates;S. Margulies;Michael Koval
通讯作者：
A. Patel;D. Reigada;C. Mitchell;S. Bates;S. Margulies;Michael Koval