Pre-treatment Serum HE4 Level as a Novel Independent Prognostic Biomarker for Uterine Cervical Carcinoma Patients.
Pre-treatment Serum HE4 Level as a Novel Independent Prognostic Biomarker for Uterine Cervical Carcinoma Patients.
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DOI：
10.3389/fonc.2020.584022
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发表时间：
2020
影响因子：
4.7
通讯作者：
Ravaggi A
中科院分区：
文献类型：
--
作者：
Bignotti E;Zanotti L;Todeschini P;Zizioli V;Romani C;Capoferri D;Tognon G;Sartori E;Calza S;Odicino F;Ravaggi A
In spite of the effective implementation of screening programs, uterine cervical carcinoma (UCC) remains one of the major causes of cancer death among women around the world. The aim of this study was to investigate the prognostic value of serum human epididymis protein 4 (HE4) in UCC. Pre-treatment serum samples from 109 UCC patients and 99 healthy women were analyzed for HE4 levels by a quantitative chemiluminescent microparticle immunoassay on the automated ARCHITECT instrument. HE4 serum (sHE4) levels were significantly higher in UCC patients, regardless of tumor stage, compared with healthy controls. Elevated sHE4 levels were significantly associated with advanced FIGO stage and absence of disease-free interval after treatment. In univariable analysis, higher sHE4 levels were significantly correlated with shorter overall survival and progression-free survival. In multivariable analysis, sHE4 retained its significance as independent adverse prognostic factor for both survival endpoints. This study indicates that sHE4 is associated with a more aggressive tumor phenotype and a worse patient's prognosis. These results suggest the potential role of sHE4 as a novel prognostic marker and as an indicator of high-risk UCC patients for a tailored surgical and adjuvant therapy.
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HE4（人附睾蛋白4）过度表达增强卵巢癌的增殖、侵袭和转移
影响因子：
--
作者：
Zhu L;Zhuang H;Wang H;Tan M;Schwab CL;Deng L;Gao J;Hao Y;Li X;Gao S;Liu J;Lin B
通讯作者：
Lin B
影响因子：
1.3
作者：
Diniz, Gulden;Karadeniz, Tugba;Akman, Tulay
通讯作者：
Akman, Tulay
影响因子：
5
作者：
Ruggeri, Giuseppina;Bandiera, Elisabetta;Pecorelli, Sergio
通讯作者：
Pecorelli, Sergio
血清人类附睾蛋白4和卵巢恶性算法的风险是上皮卵巢癌管理的新诊断和预后工具。
DOI：
10.1158/1055-9965.epi-11-0635
发表时间：
2011-12
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
Bandiera E;Romani C;Specchia C;Zanotti L;Galli C;Ruggeri G;Tognon G;Bignotti E;Tassi RA;Odicino F;Caimi L;Sartori E;Santin AD;Pecorelli S;Ravaggi A
通讯作者：
Ravaggi A
影响因子：
3.5
作者：
Jurgenliemk-Schulz, Ina-Maria;Beriwal, Sushi;Erickson, Beth
通讯作者：
Erickson, Beth