Autworks: a cross-disease network biology application for Autism and related disorders.
Autworks: a cross-disease network biology application for Autism and related disorders.
复制标题
DOI：
10.1186/1755-8794-5-56
复制
发表时间：
2012-11-28
影响因子：
2.7
通讯作者：
Wall DP
中科院分区：
文献类型：
--
作者：
Nelson TH;Jung JY;Deluca TF;Hinebaugh BK;St Gabriel KC;Wall DP
自闭症的遗传病因是多种多样的。多种疾病与自闭症具有相同的基因型和表型特征。基于网络的跨疾病分析可以帮助理解和表征自闭症的分子病理学，但很少有工具使我们能够进行跨疾病分析并将结果可视化。我们将 Autoworks 设计为一个门户网站，汇集自闭症的基因相互作用和基因疾病关联数据，从而实现网络构建、可视化以及与许多其他相关神经系统疾病和疾病的网络比较。用户可以检查一组疾病相关基因内的基因相互作用的结构，将疾病/疾病基因网络与其他疾病/疾病基因网络进行比较，并上传他们自己的基因组进行比较分析。 Autoworks 是一个网络应用程序，为不同背景的研究人员提供易于使用的资源，以分析疾病内部和疾病之间的自闭症基因网络结构。可用性：http://autworks.hms.harvard.edu/
The genetic etiology of autism is heterogeneous. Multiple disorders share genotypic and phenotypic traits with autism. Network based cross-disorder analysis can aid in the understanding and characterization of the molecular pathology of autism, but there are few tools that enable us to conduct cross-disorder analysis and to visualize the results. We have designed Autworks as a web portal to bring together gene interaction and gene-disease association data on autism to enable network construction, visualization, network comparisons with numerous other related neurological conditions and disorders. Users may examine the structure of gene interactions within a set of disorder-associated genes, compare networks of disorder/disease genes with those of other disorders/diseases, and upload their own sets for comparative analysis. Autworks is a web application that provides an easy-to-use resource for researchers of varied backgrounds to analyze the autism gene network structure within and between disorders. Availability: http://autworks.hms.harvard.edu/
登录
查看更多内容
影响因子：
14.9
作者：
Keshava Prasad TS;Goel R;Kandasamy K;Keerthikumar S;Kumar S;Mathivanan S;Telikicherla D;Raju R;Shafreen B;Venugopal A;Balakrishnan L;Marimuthu A;Banerjee S;Somanathan DS;Sebastian A;Rani S;Ray S;Harrys Kishore CJ;Kanth S;Ahmed M;Kashyap MK;Mohmood R;Ramachandra YL;Krishna V;Rahiman BA;Mohan S;Ranganathan P;Ramabadran S;Chaerkady R;Pandey A
通讯作者：
Pandey A
影响因子：
6.9
作者：
BAILEY, A;LECOUTEUR, A;RUTTER, M
通讯作者：
RUTTER, M
DOI：
10.1073/pnas.1112667108
发表时间：
2011-09-13
影响因子：
11.1
作者：
Bader, Patrick L.;Faizi, Mehrdad;Shamloo, Mehrdad
通讯作者：
Shamloo, Mehrdad
影响因子：
30.8
作者：
Allen, Nicole C.;Bagade, Sachin;Bertram, Lars
通讯作者：
Bertram, Lars
影响因子：
--
作者：
Hallmayer, Joachim;Cleveland, Sue;Torres, Andrea;Phillips, Jennifer;Cohen, Brianne;Torigoe, Tiffany;Miller, Janet;Fedele, Angie;Collins, Jack;Smith, Karen;Lotspeich, Linda;Croen, Lisa A.;Ozonoff, Sally;Lajonchere, Clara;Grether, Judith K.;Risch, Neil
通讯作者：
Risch, Neil