Roles of CD147 on T lymphocytes activation and MMP-9 secretion in systemic lupus erythematosus.
Roles of CD147 on T lymphocytes activation and MMP-9 secretion in systemic lupus erythematosus.
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DOI：
10.1111/j.1582-4934.2007.00022.x
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发表时间：
2007-03
影响因子：
5.3
通讯作者：
Stefanescu M
中科院分区：
文献类型：
--
作者：
Pistol G;Matache C;Calugaru A;Stavaru C;Tanaseanu S;Ionescu R;Dumitrache S;Stefanescu M
系统性红斑狼疮（SLE）中描述的许多异常所涉及的细胞和分子机制仍不清楚。其中一些异常是指T淋巴细胞的过度活化和外周血单核细胞（PBMC）分泌MMP-9的增强。因此，在本文中，我们研究了CD 147分子在这些异常中的潜在作用。我们的研究结果表明，CD 147分子过表达的CD 3 + T淋巴细胞从SLE患者相比，从健康供体的CD 3 + T淋巴细胞。抗CD 147单克隆抗体MEM-M6/1克隆仅能抑制SLE患者CD 3 × CD 28共刺激的T淋巴细胞蛋白酪氨酸磷酸化。然而，这种单克隆抗体不能抑制SLE PBMC分泌的MMP-9的增强活性。
The cellular and molecular mechanisms involved in many abnormalities described in Systemic Lupus Erythematosus (SLE) are still unclear. Some of these abnormalities referred to the hyperactivation of T lymphocytes and the enhanced secretion of MMP-9 by peripheral blood mononuclear cells (PBMCs). Therefore, in this paper we investigated the potential role of CD147 molecule in these abnormalities. Our results demonstrated that CD147 molecule is overexpressed on CD3+T lymphocytes from SLE patients when compared with CD3+T lymphocytes from healthy donors. Monoclonal anti-CD147 antibodies, MEM-M6/1 clone, were able to inhibit protein tyrosine phosphorylation only in CD3 × CD28 costimulated T lymphocytes from SLE patients. However, this monoclonal antibody was unable to inhibit the enhanced activity of MMP-9 secreted by SLE PBMCs.
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作者：
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发表时间：
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影响因子：
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