Altered expression of cell adhesion molecules in uninvolved gut in inflammatory bowel disease
Altered expression of cell adhesion molecules in uninvolved gut in inflammatory bowel disease
复制标题
炎症性肠病未受累肠道中细胞粘附分子表达的改变
DOI：
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发表时间：
1993
影响因子：
4.6
通讯作者：
Julia M. Polak
中科院分区：
文献类型：
--
作者：
G. M. Schuermann;A. E. Aber;Paul Facer;J. C. Lee;D. S. RAMPTONt;C. J. DORtE;Julia M. Polak
循环细胞与血管内皮细胞的粘附发生在炎症的早期阶段，并由特异性细胞粘附分子介导。许多这样的粘附分子在溃疡性结肠炎（UC）和克罗恩病（CD）的发炎区域中增加，但对其在邻近炎症的未受累肠道中的表达的了解有限。我们研究了血小板内皮细胞粘附分子-1（PECAM-1）、细胞间粘附分子-1（ICAM-1）和淋巴细胞功能相关抗原-1（LFA-1）的表达。在距炎症区域2 - 4 cm处采集的切除标本上，且无炎症的组织学体征。与正常肠道相比。我们发现（i）未受累UC粘膜中PECAM-1阳性血管显著增加（149.0 ± 24.1 vesscls/mm 2（平均值± s.d.）;正常结肠= 123.1 ± 21.6; P= 0.004）;（ii）未受累CD中ICAM-1阳性血管显著减少（111.9 ± 22.6血管/mm 2正常回肠= 136.9 ± 27.6; P=0.04）;（iii）未受累UC和克罗恩氏回肠炎粘膜中LFA-1阳性细胞中度但统计学上不显著增加。这种细胞粘附分子表达的改变可能有助于炎症性肠病的早期病变，并提供新的治疗机会。
Adhesion of circulating cells to vascular endothelium occurs in the early phase orinfiammation, and is mediated by specific cell adhesion molecules. Many such adhesion molecules are increased in inflamed regions of ulcerative colitis (UC) and Crohn's disease (CD) but there is limited knowledge of their expression in the uninvolved gut, adjacent to inflammation. We investigated immunohisto‐chemically the expression of platelet endoihelial cell adhesion moleculc‐1 (PECAM‐1), intercellular adhesion molecule‐l (ICAM‐l)and lymphocyte function‐associated antigen‐1 (LFA‐1.) on resected specimens taken at a distance of 2‐4 cm from the inflamed area and without histological signs of inflammation. Compared with normal gut. we found (i) a significant increase of PECAM‐1‐positive vessels in the mucosa of uninvolved UC (149.0 ± 24.1 vesscls/mm2 (mean ± s.d.); normal colon = 123.1 ± 21.6; P= 0.004); (ii)a significant decrease of ICAM‐1‐positive vessels in uninvolved CD (111.9 ± 22.6 vessels/mm2 normal ileum = 136.9 ± 27.6; P=0.04); and (iii) a moderate but statistically insignificant increase of LFA‐1 ‐positive cells in the mucosa of uninvolved UC and Crohn's ileitis. This altered expression of cell adhesion molecules may contribute to the early lesion in inflammatory bowel disease and provide new therapeutic opportunities.
一种针对促进粘附的白细胞糖蛋白 CD18 的单克隆抗体，可减少兔子的器官损伤并提高失血性休克和复苏的存活率。
DOI：
10.1172/jci113407
发表时间：
1988
期刊：
The Journal of clinical investigation
影响因子：
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作者：
Vedder,NB;Winn,RK;Rice,CL;Chi,EY;Arfors,KE;Harlan,JM
通讯作者：
Harlan,JM
影响因子：
15.9
作者：
SMITH, CW;MARLIN, SD;ANDERSON, DC
通讯作者：
ANDERSON, DC
影响因子：
56.9
作者：
NEWMAN, PJ;BERNDT, MC;MULLER, WA
通讯作者：
MULLER, WA