Effects and underlying mechanisms of curcumin on the proliferation of vascular smooth muscle cells induced by Chol:MbetaCD.
Effects and underlying mechanisms of curcumin on the proliferation of vascular smooth muscle cells induced by Chol:MbetaCD.
复制标题
DOI：
10.1016/j.bbrc.2008.12.038
复制
发表时间：
2009-02-06
影响因子：
3.1
通讯作者：
Liao DF
中科院分区：
文献类型：
--
作者：
Qin L;Yang YB;Tuo QH;Zhu BY;Chen LX;Zhang L;Liao DF
Proliferation of vascular smooth muscle cells (VSMCs) contributes to the development of various cardiovascular diseases. Curcumin, extracted from curcumae longae, has been shown a variety of beneficial effects on human health, including anti-atherosclerosis by mechanisms poorly understood. In the present study, we attempted to investigate whether curcumin has any effect on VSMCs proliferation and the potential mechanisms involved. Our data showed curcumin concentration-dependently abrogated the proliferation of primary rat VSMCs induced by Chol:MßCD. To explore the underlying cellular and molecular mechanisms, we found that curcumin was capable of restoring caveolin-1 expression which was reduced by Chol:MßCD treatment. Moreover, curcumin abrogated the increment of phospho-ERK1/2 and nuclear accumulation of ERK1/2 in primary rat VSMCs induced by Chol:MßCD, which led to a suppression of AP1 promoter activity stimulated by Chol:MßCD. In addition, curcumin was able to reverse cell cycle progression induced by Chol:MßCD, which was further supported by its down-regulation of cyclinD1 and E2F promoter activities in the presence of Chol:MßCD. Taking together, our data suggest curcumin inhibits Chol:MßCD-induced VSMCs proliferation via restoring caveolin-1 expression that leads to the suppression of over-activated ERK signaling and causes cell cycle arrest at G1/S phase. These novel findings support the beneficial potential of curcumin in cardiovascular disease.
登录
查看更多内容
罗格列酮对高糖诱导血管平滑肌细胞增殖的影响
影响因子：
3.4
作者：
Ling, Hong-Yan;Hu, Bi;Liao, Duan-Fang
通讯作者：
Liao, Duan-Fang
影响因子：
64.5
作者：
ROTHBERG, KG;HEUSER, JE;ANDERSON, RGW
通讯作者：
ANDERSON, RGW
影响因子：
12.8
作者：
Pae, Hyun-Ock;Jeong, Gil-Saeng;Chung, Hun-Taeg
通讯作者：
Chung, Hun-Taeg
DOI：
10.1152/ajpregu.00858.2006
发表时间：
2007-06-01
影响因子：
2.8
作者：
Davis, J. Mark;Murphy, E. Angela;Mayer, Eugene P.
通讯作者：
Mayer, Eugene P.
影响因子：
6.1
作者：
Liu, Hai-Mei;Zhao, Xiao-Feng;Wang, Ting-Huai
通讯作者：
Wang, Ting-Huai