An examination of autism spectrum traits in adolescents with anorexia nervosa and their parents.
An examination of autism spectrum traits in adolescents with anorexia nervosa and their parents.
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DOI：
10.1186/2040-2392-5-56
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发表时间：
2014
期刊：
影响因子：
6.2
通讯作者：
Treasure J
中科院分区：
文献类型：
--
作者：
Rhind C;Bonfioli E;Hibbs R;Goddard E;Macdonald P;Gowers S;Schmidt U;Tchanturia K;Micali N;Treasure J
神经性厌食症和自闭症谱系障碍之间可能存在联系。这项研究的目的是检查青少年神经性厌食症是否有自闭症谱系和/或强迫症特征，有多少人符合自闭症谱系障碍的诊断标准，以及这些特征是否由父母共享。共有150名接受神经性厌食症或阈下神经性厌食症门诊治疗的青少年及其父母完成了发育和幸福感评估的自闭症谱系障碍和饮食障碍部分。患者还完成了儿童耶鲁-布朗强迫量表和其他精神病发病率的测量，父母完成了简短的自闭症商数和强迫量表修订版。患有神经性厌食症的青少年社交能力低于平均水平（低于截止值19%），同伴关系问题（高于截止值39%）和强迫症状（高于截止值56%）水平较高。6例病例（4%，均为女性）被指定为可能（n = 5）或明确（n = 1）诊断为自闭症谱系障碍。父母的自闭症谱系和强迫症特征水平在正常范围内。这项研究表明，患有神经性厌食症的青少年具有较高水平的自闭症谱系特征，强迫症状，并且一小部分符合可能的自闭症谱系障碍的诊断标准。这些特征似乎不是家族性的。这种合并症与较差的预后相关。因此，可能需要调整该亚组的治疗。Controlled-trials.com：ISRCTN83003225。2011年9月29日登记。
There may be a link between anorexia nervosa and autism spectrum disorders. The aims of this study were to examine whether adolescents with anorexia nervosa have autism spectrum and/or obsessive-compulsive traits, how many would meet diagnostic criteria for autism spectrum disorder, and whether these traits are shared by parents. A total of 150 adolescents receiving outpatient treatment for anorexia nervosa or subthreshold anorexia nervosa and their parents completed the autism spectrum disorder and eating disorder sections of the Development and Well-being Assessment. Patients also completed the Children Yale-Brown Obsessive-Compulsive Scale and other measures of psychiatric morbidity, and parents completed the short Autism Quotient and Obsessive-Compulsive Inventory Revised. Adolescents with anorexia nervosa had a below average social aptitude (19% below cut-off) and high levels of peer relationship problems (39% above cut-off) and obsessive-compulsive symptoms (56% above cut-off). Six cases (4%, all females) were assigned a possible (n = 5) or definite (n = 1) diagnosis of autism spectrum disorder. Parental levels of autism spectrum and obsessive-compulsive traits were within the normal range. This study suggests that adolescents with anorexia nervosa have elevated levels of autism spectrum traits, obsessive-compulsive symptoms, and a small proportion fulfil diagnostic criteria for a probable autism spectrum disorder. These traits did not appear to be familial. This comorbidity has been associated with a poorer prognosis. Therefore, adaptation of treatment for this subgroup may be warranted. Controlled-trials.com: ISRCTN83003225. Registered on 29 September 2011.
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影响因子：
3.6
作者：
Foa, EB;Huppert, JD;Salkovskis, PM
通讯作者：
Salkovskis, PM
DOI：
10.1097/00004583-200107000-00017
发表时间：
2001-07-01
影响因子：
13.3
作者：
Fombonne, E;Simmons, H;Goodman, R
通讯作者：
Goodman, R
影响因子：
5.3
作者：
Hughes, Elizabeth K.;Goldschmidt, Andrea B.;Le Grange, Daniel
通讯作者：
Le Grange, Daniel
影响因子：
6.2
作者：
Baron-Cohen, Simon;Jaffa, Tony;Wheelwright, Sally
通讯作者：
Wheelwright, Sally
影响因子：
3.2
作者：
Krug, Isabel;Penelo, Eva;Treasure, Janet
通讯作者：
Treasure, Janet