Surface modification of graphene nanopores for protein translocation.
Surface modification of graphene nanopores for protein translocation.
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DOI：
10.1088/0957-4484/24/49/495102
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发表时间：
2013-12-13
期刊：
影响因子：
3.5
通讯作者：
He J
中科院分区：
文献类型：
--
作者：
Shan YP;Tiwari PB;Krishnakumar P;Vlassiouk I;Li WZ;Wang XW;Darici Y;Lindsay SM;Wang HD;Smirnov S;He J
Studies of DNA translocation through graphene nanopores have revealed their potential for DNA sequencing. Here we report a study of protein translocation through chemically modified graphene nanopores. A transmission electron microscope (TEM) was used to cut nanopores with diameters between 5-20 nm in multilayer graphene prepared by chemical vapor deposition (CVD). After oxygen plasma treatment, the dependence of the measured ionic current on salt concentration and pH was consistent with a small surface charge induced by the formation of carboxyl groups. While translocation of gold nanoparticles (10 nm) was readily detected through such treated pores of a larger diameter, translocation of protein ferritin was not observed either for oxygen plasma treated pores, or for pores modified with mercaptohexadecanoic acid. Ferritin translocation events were reliably observed after the pores were modified with the phospholipid-PEG (DPPE-PEG750) amphiphile. The ion current signature of translocation events was complex, suggesting that a series of interactions between the protein and pore occur during the process.
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