Upregulation of LINC00659 expression predicts a poor prognosis and promotes migration and invasion of gastric cancer cells.
Upregulation of LINC00659 expression predicts a poor prognosis and promotes migration and invasion of gastric cancer cells.
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DOI：
10.3892/ol.2021.12818
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发表时间：
2021-07
期刊：
影响因子：
2.9
通讯作者：
Fan H
中科院分区：
文献类型：
--
作者：
Gong P;Xu Y;Liu M;Shen X;Mao Y;Li Y;Zhang K;Yu S;Fan H
长链非编码RNA（lncRNA）在癌症的进展中起重要作用。LINC00659是最近发现的一种新的致癌lncRNA，通过调节细胞周期参与结肠癌细胞增殖。然而，LINC00659在其他类型的癌症，特别是胃癌（GC）中的功能仍然未知。本研究通过生物信息学分析结合细胞实验研究LINC00659在胃癌中的作用。结果显示，LINC00659在胃癌组织和细胞系中表达显著上调。LINC00659水平升高与胃癌患者的晚期肿瘤分期和不良预后相关。此外，上调LINC00659表达促进GC细胞的迁移和侵袭。使用生物信息学方法的进一步分析显示，基质金属蛋白酶15和含有IQ基序的GT3活化蛋白3是LINC00659参与肿瘤转移的潜在下游靶点，尽管精确的潜在机制需要进一步探索。
Long non-coding RNAs (lncRNAs) serve an important role in the progression of cancer. LINC00659 was recently identified as a novel oncogenic lncRNA involved in colon cancer cell proliferation via modulating the cell cycle. However, the function of LINC00659 in other types of cancer, especially in gastric cancer (GC), remains unknown. In the present study, bioinformatics analysis combined with cell experiments were performed to explore the function of LINC00659 in GC. It was revealed that LINC00659 expression was significantly upregulated in GC tissues and cell lines. Increased levels of LINC00659 were associated with advanced tumor stage and unfavorable prognosis of patients with GC. Additionally, upregulated LINC00659 expression promoted the migration and invasion of GC cells. Further analysis using a bioinformatics method revealed that matrix metalloproteinase 15 and IQ motif-containing GTPase activating protein 3 were potential downstream targets of LINC00659 involved in tumor metastasis, although the precise underlying mechanism requires further exploration.
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影响因子：
4
作者：
Nasrollahzadeh-Khakiani, Mojdeh;Emadi-Baygi, Modjtaba;Nikpour, Parvaneh
通讯作者：
Nikpour, Parvaneh
过表达长非编码RNA HOXA11-AS促进胃癌细胞周期进展和转移
影响因子：
37.3
作者：
Liu Z;Chen Z;Fan R;Jiang B;Chen X;Chen Q;Nie F;Lu K;Sun M
通讯作者：
Sun M
DOI：
10.1158/1541-7786.mcr-16-0352
发表时间：
2017-06
期刊：
Molecular cancer research : MCR
影响因子：
--
作者：
Ptashkin RN;Pagan C;Yaeger R;Middha S;Shia J;O'Rourke KP;Berger MF;Wang L;Cimera R;Wang J;Klimstra DS;Saltz L;Ladanyi M;Zehir A;Hechtman JF
通讯作者：
Hechtman JF
影响因子：
11.2
作者：
Bhan A;Soleimani M;Mandal SS
通讯作者：
Mandal SS
影响因子：
64.5
作者：
Rinn, John L.;Kertesz, Michael;Chang, Howard Y.
通讯作者：
Chang, Howard Y.