Caffeoylxanthiazonoside exerts cardioprotective effects during chronic heart failure via inhibition of inflammatory responses in cardiac cells.
Caffeoylxanthiazonoside exerts cardioprotective effects during chronic heart failure via inhibition of inflammatory responses in cardiac cells.
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咖啡酰黄噻酮苷通过抑制心肌细胞的炎症反应在慢性心力衰竭期间发挥心脏保护作用
DOI：
10.3892/etm.2017.5080
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发表时间：
2017-11
影响因子：
2.7
通讯作者：
Li B
中科院分区：
文献类型：
--
作者：
Yang B;Wang F;Cao H;Liu G;Zhang Y;Yan P;Li B
CYT是一种从苍耳菌（Xanthium strumarium L）果实中分离得到的活性成分。本研究的目的是探讨口服CYT对慢性心力衰竭（CHF）的心脏保护作用及其潜在机制。首先建立CHF大鼠模型，通过心脏超声测定心脏/体重指数、左心/体重指数、缩短分数（FS）、射血分数（EF）、心输出量（CO）、心率（HR）等心功能指标。采用ELISA法检测各组大鼠血清乳酸脱氢酶（LDH）、肌酸激酶（CK）水平，以及心脏组织和心脏微血管内皮细胞（CMECs）中肿瘤坏死因子(TNF)-α、白细胞介素(IL)-6、IL-1β等促炎因子水平。western blot检测核因子-κB （NF-κB）信号通路成员蛋白表达水平。结果表明，与CHF模型大鼠相比，口服CYT 10、20、40 mg/kg可显著降低心肌肥厚，逆转FS、EF、CO和HR。此外，CYT可显著降低大鼠心脏组织中TNF-α、IL-6、IL-1β水平及血清LDH、CK水平。此外，暴露于20、40和80µg/ml CYT的cmes显著降低TNF-α、IL-1β和IL-6的产生。与未处理的CHF模型对照组相比，20、40和80µg/ml CYT处理cmes后，细胞质NF-κB p65和i -κB蛋白表达水平上调，核NF-κB p65表达水平下调。综上所述，本研究结果提示，CYT通过抑制促炎细胞因子的表达和NF-κB信号通路，对CHF模型大鼠具有心脏保护作用。
Caffeoylxanthiazonoside (CYT) is an active constituent isolated from the fruit of the Xanthium strumarium L plant. The aim of the present study was to investigate the cardioprotective effects of oral administration of CYT on chronic heart failure (CHF) and its underlying mechanisms. A rat model of CHF was first established, and cardiac function indices, including the heart/body weight index, left heart/body weight index, fractional shortening (FS), ejection fraction (EF), cardiac output (CO) and heart rate (HR), were subsequently determined by cardiac ultrasound. Serum levels of lactate dehydrogenase (LDH) and creatine kinase (CK), and the levels of pro-inflammatory cytokines, including tumor necrosis factor (TNF)-α, interleukin (IL)-6 and IL-1β in heart tissues and cardiac microvascular endothelial cells (CMECs) were determined using ELISA. In addition, the protein expression levels of nuclear factor-κB (NF-κB) signaling pathway members were determined by western blotting in CMECs. The results demonstrated that oral administration of 10, 20, 40 mg/kg CYT significantly reduced cardiac hypertrophy and reversed FS, EF, CO and HR when compared with CHF model rats. In addition, CYT administration significantly decreased the levels of TNF-α, IL-6 and IL-1β in heart tissues, as well as serum LDH and CK levels. Furthermore, exposure of CMECs to 20, 40 and 80 µg/ml CYT significantly decreased the production of TNF-α, IL-1β and IL-6. The protein expression levels of cytoplasmic NF-κB p65 and IκB were upregulated, while nuclear NF-κB p65 was downregulated following treatment of CMECs with 20, 40 and 80 µg/ml CYT when compared with untreated CHF model controls. In conclusion, the results of the current study suggest that CYT demonstrates cardioprotective effects in CHF model rats by suppressing the expression of pro-inflammatory cytokines and the NF-κB signaling pathway.
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影响因子：
3.7
作者：
Yuan X;Niu HT;Wang PL;Lu J;Zhao H;Liu SH;Zheng QS;Li CG
通讯作者：
Li CG
基于生物活性集成UPLC-Q/TOF MS鉴定芪参益气滴丸治疗心肌梗死中NF-κB抑制剂
影响因子：
1.8
作者：
Han, Yanqi;Zhou, Mengge;Luo, Guoan
通讯作者：
Luo, Guoan
影响因子：
3.3
作者：
He, Chang-Liang;Yi, Peng-Fei;Fu, Ben-Dong
通讯作者：
Fu, Ben-Dong
β酸对大鼠心肌缺血再灌注损伤的心脏保护作用。
DOI：
10.1155/2014/573745
发表时间：
2014
期刊：
Evidence-based complementary and alternative medicine : eCAM
影响因子：
--
作者：
Xia A;Xue Z;Li Y;Wang W;Xia J;Wei T;Cao J;Zhou W
通讯作者：
Zhou W
DOI：
10.1152/ajpheart.01245.2003
发表时间：
2004-10-01
影响因子：
4.8
作者：
Zhu, GQ;Gao, L;Wang, W
通讯作者：
Wang, W