ERG and Behavioral CFF in Light-Damaged Albino Rats.
ERG and Behavioral CFF in Light-Damaged Albino Rats.
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DOI：
10.3390/ijms23084127
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发表时间：
2022-04-08
影响因子：
5.6
通讯作者：
Kraft, Timothy W.
中科院分区：
文献类型：
--
作者：
Rubin, Glen R.;Wen, Yuquan;Loop, Michael S.;Kraft, Timothy W.
在啮齿类动物视网膜变性模型中，全视场ERG对杆状或锥体介导的视网膜功能指数是有用的。然而，ERG反应幅度与视觉引导行为（如闪烁检测）之间的关系尚不清楚。在视网膜变性的光损伤模型中，ERG与行为反应的比较使我们能够更好地理解电生理变化的功能含义。采用闪烁- erg和对闪烁的行为反应来确定低强度光损伤前和10天后90 d内暗暗和光条件下的临界闪烁频率（CFF）。光损伤后，暗适应和适应光的ERG闪光反应显著降低。a波的振幅永久性降低，而b波的振幅在光损伤后三周内恢复。阴离子ERG CFF有小但显著的下降。光损伤后的光致行为CFF略低。b波振幅和闪烁灵敏度的恢复显示了光损伤后视网膜回路的可塑性。
The full-field ERG is useful for index rod- or cone-mediated retinal function in rodent models of retinal degeneration. However, the relationship between the ERG response amplitudes and visually guided behavior, such as flicker detection, is not well understood. A comparison of ERG to behavioral responses in a light-damage model of retinal degeneration allows us to better understand the functional implications of electrophysiological changes. Flicker-ERG and behavioral responses to flicker were used to determine critical flicker frequency (CFF) under scotopic and photopic conditions before and up to 90 d after a 10-day period of low-intensity light damage. Dark- and light-adapted ERG flash responses were significantly reduced after light damage. The a-wave was permanently reduced, while the b-wave amplitude recovered over three weeks after light damage. There was a small, but significant dip in scotopic ERG CFF. Photopic behavioral CFF was slightly lower following light damage. The recovery of the b-wave amplitude and flicker sensitivity demonstrates the plasticity of retinal circuits following photopic injury.
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影响因子：
5.6
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