Physiological changes throughout an insect ear due to age and noise - A longitudinal study.
Physiological changes throughout an insect ear due to age and noise - A longitudinal study.
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DOI：
10.1016/j.isci.2022.104746
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发表时间：
2022-09-16
期刊：
影响因子：
5.8
通讯作者：
Warren, Ben
中科院分区：
文献类型：
--
作者：
Blockley, Alix;Ogle, Daisy;Woodrow, Charlie;Montealegre-Z, Fernando;Warren, Ben
听力损失并非人类所独有，所有动物在面对耳朵形态的巨大差异时都会经历听力损失。在这里，我们利用沙漠蝗虫 Schistocerca gregaria 的高通量和可接触的鼓室耳朵来严格量化由于噪声暴露和年龄而引起的听觉系统的变化。在这项探索性研究中，我们分析了鼓室位移、听觉穆勒器官的形态，并测量了听觉神经的活动、传导电流和个体听觉感受器的电生理特性。这项工作表明，由于年龄和噪音对耳内多种过程和细胞类型的不同影响，听力损失表现为一种复杂的疾病。蝗虫中发现的“中年耳聋”听力损失模式与早年接触噪音的人类相似，这表明听觉系统（噪音）的使用与其衰老之间存在根本的相互作用。经常暴露在噪音中的蝗虫会出现与人类相同的听力损失模式。听觉系统的某些部分会受到噪音、年龄或噪音和年龄两者的影响。听力损失是一种多方面的疾病，由不同耳突的缺陷引起。动物行为学；细胞神经科学；感觉神经科学
Hearing loss is not unique to humans and is experienced by all animals in the face of wild and eclectic differences in ear morphology. Here, we exploited the high throughput and accessible tympanal ear of the desert locust, Schistocerca gregaria to rigorously quantify changes in the auditory system due to noise exposure and age. In this exploratory study, we analyzed tympanal displacements, morphology of the auditory Müller’s organ and measured activity of the auditory nerve, the transduction current, and electrophysiological properties of individual auditory receptors. This work shows that hearing loss manifests as a complex disorder due to differential effects of age and noise on several processes and cell types within the ear. The “middle-aged deafness” pattern of hearing loss found in locusts mirrors that found for humans exposed to noise early in their life suggesting a fundamental interaction of the use of an auditory system (noise) and its aging. Locusts routinely exposed to noise follow same pattern of hearing loss as humans Parts of the auditory system are affected by noise, age, or both noise and age Hearing loss is a multifaceted disorder caused by defects in distinct ear processes Entomology; Ethology; Cellular neuroscience; Sensory neuroscience
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影响因子：
2.4
作者：
Echt, Katharina V.;Smith, Sherri L.;Spiro, Avron, III
通讯作者：
Spiro, Avron, III
影响因子：
2.4
作者：
CLARK, WW;CLARK, CS;STEBBINS, WC
通讯作者：
STEBBINS, WC
影响因子：
1.4
作者：
DAYAL, VS;BHATTACHARYYA, TK
通讯作者：
BHATTACHARYYA, TK
影响因子：
5.3
作者：
Fetoni, Anna Rita;De Bartolo, Paola;Troiani, Diana
通讯作者：
Troiani, Diana
影响因子：
5.8
作者：
Boyd-Gibbins N;Tardieu CH;Blunskyte M;Kirkwood N;Somers J;Albert JT
通讯作者：
Albert JT