Turnover and activity-dependent transcriptional control of NompC in the Drosophila ear.
Turnover and activity-dependent transcriptional control of NompC in the Drosophila ear.
复制标题
果蝇耳中NompC的周转和活性依赖性转录控制。
DOI：
10.1016/j.isci.2021.102486
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发表时间：
2021-05-21
期刊：
影响因子：
5.8
通讯作者：
Albert JT
中科院分区：
文献类型：
--
作者：
Boyd-Gibbins N;Tardieu CH;Blunskyte M;Kirkwood N;Somers J;Albert JT
在生物传感器的整个生命过程中，尽管受到无数的外源和内源扰动，它们仍保持着几乎不变的功能输出。这种感觉动态平衡是多种动态平衡的产物，动态平衡的破坏会导致与年龄相关的衰退。然而，维持体内平衡的机制仍然知之甚少。脊椎动物和昆虫的耳朵具有精致的敏感性，但也具有明显的功能脆弱性。由于处于热和声学噪声的永久负荷下，听觉换能器通道就是动态平衡挑战的例证。我们发现：(1)果蝇耳朵中依赖于NompC的机械转导器经历了持续的替换，估计周转时间为9.1h；(2)NompC的从头合成可以恢复先天性听力障碍果蝇成年耳朵的转导功能；(3)包括NompC在内的听觉转导链的关键组件受到活动依赖的转录控制，很可能形成一个延伸到听力器官以外的转导机制。NompC的合成恢复了先天耳聋果蝇的听觉传导。NompC机械式换能器在24小时内完成周转。转导分子的活性依赖转录控制控制听觉功能。生物科学；分子生物学；感觉神经科学
Across their lives, biological sensors maintain near-constant functional outputs despite countless exogenous and endogenous perturbations. This sensory homeostasis is the product of multiple dynamic equilibria, the breakdown of which contributes to age-related decline. The mechanisms of homeostatic maintenance, however, are still poorly understood. The ears of vertebrates and insects are characterized by exquisite sensitivities but also by marked functional vulnerabilities. Being under the permanent load of thermal and acoustic noise, auditory transducer channels exemplify the homeostatic challenge. We show that (1) NompC-dependent mechanotransducers in the ear of the fruit fly Drosophila melanogaster undergo continual replacement with estimated turnover times of 9.1 hr; (2) a de novo synthesis of NompC can restore transducer function in the adult ears of congenitally hearing-impaired flies; (3) key components of the auditory transduction chain, including NompC, are under activity-dependent transcriptional control, likely forming a transducer-operated mechanosensory gain control system that extends beyond hearing organs. De novo NompC synthesis restores auditory transduction in congenitally deafened flies. Complete turnover of NompC mechanotransducers within less than 24 hr. Activity-dependent transcriptional control of transducers controls auditory function. Biological sciences ; Molecular biology ; Sensory neuroscience
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影响因子：
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