Primary cilia and ciliary signaling pathways in aging and age-related brain disorders.
Primary cilia and ciliary signaling pathways in aging and age-related brain disorders.
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DOI：
10.1016/j.nbd.2021.105607
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发表时间：
2022-03
影响因子：
6.1
通讯作者：
Hu, Guoku
中科院分区：
文献类型：
--
作者：
Ma, Rong;Kutchy, Naseer A.;Chen, Liang;Meigs, Douglas D.;Hu, Guoku
关键词：
脑疾病的特征在于由于神经细胞的进行性变性和/或死亡而导致的脑结构和功能的进行性丧失。衰老是脑疾病如阿尔茨海默病（AD）、帕金森病（PD）、肌萎缩侧索硬化（ALS）和中风的主要危险因素。各种细胞和分子事件已被证明在神经退行性疾病的进展中发挥作用。新的研究表明，初级纤毛可能是脑部疾病的关键调节器。初级纤毛是一种单一的细胞器，表达在许多细胞类型的表面，如成熟大脑中的星形胶质细胞和神经元。初级纤毛检测细胞外信号，如Sonic Hedgehog（SHH）蛋白，并将这些信号传递到细胞内以调节各种信号通路。纤毛长度和频率（纤毛细胞的比例）的异常与各种人类疾病有关，包括大脑疾病。这篇综述总结了目前关于初级纤毛和纤毛信号通路在衰老和与年龄相关的脑部疾病中的作用的发现和想法。
Brain disorders are characterized by the progressive loss of structure and function of the brain as a consequence of progressive degeneration and/or death of nerve cells. Aging is a major risk factor for brain disorders such as Alzheimer’s disease (AD), Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS), and stroke. Various cellular and molecular events have been shown to play a role in the progress of neurodegenerative diseases. Emerging studies suggest that primary cilia could be a key regulator in brain diseases. The primary cilium is a singular cellular organelle expressed on the surface of many cell types, such as astrocytes and neurons in the mature brain. Primary cilia detect extracellular cues, such as Sonic Hedgehog (SHH) protein, and transduce these signals into cells to regulate various signaling pathways. Abnormalities in ciliary length and frequency (ratio of ciliated cells) have been implicated in various human diseases, including brain disorders. This review summarizes current findings and thoughts on the role of primary cilia and ciliary signaling pathways in aging and age-related brain disorders.
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影响因子：
2.4
作者：
Ma X;Turnbull P;Peterson R;Turnbull J
通讯作者：
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影响因子：
4.2
作者：
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影响因子：
5.5
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Abdullahi, Wazir;Tripathi, Dinesh;Ronaldson, Patrick T.
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影响因子：
5.6
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影响因子：
5.3
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