Priming With Intermittent Theta Burst Transcranial Magnetic Stimulation Promotes Spinal Plasticity Induced by Peripheral Patterned Electrical Stimulation.
Priming With Intermittent Theta Burst Transcranial Magnetic Stimulation Promotes Spinal Plasticity Induced by Peripheral Patterned Electrical Stimulation.
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DOI：
10.3389/fnins.2018.00508
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发表时间：
2018
影响因子：
4.3
通讯作者：
Huang YZ
中科院分区：
文献类型：
--
作者：
Yamaguchi T;Fujiwara T;Lin SC;Takahashi Y;Hatori K;Liu M;Huang YZ
本研究通过观察运动皮层间歇性θ波爆发经颅磁刺激（iTBS）和腓总神经外周模式电刺激（PES）之间的相互作用，探讨皮质脊髓活动对脊柱可塑性的影响。健康志愿者（n = 10）分三个阶段分别对运动皮质的胫骨前肌区（TA）和CPN的PES进行iTBS治疗：(1)iTBS- PES前，(2)iTBS- PES后，(3)假iTBS- PES前。PES协议每2秒使用10个100 hz脉冲，持续20分钟。在基线、PES前、PES后0、15、30和45分钟评估TA对比目鱼肌的相互抑制（RI）和TA和比目鱼肌的运动皮质兴奋性。与其他方案相比，itbs在PES前显著增加了15分钟的突触前RI变化，并在PES后立即改变了长环突触前抑制。此外，在PES之前，itbs诱导的TA皮质兴奋性变化与PES后立即的失突触RI增强相关。这些结果表明，脊髓可塑性可以通过改变皮质兴奋性来改变。这项研究提供了皮质脊髓兴奋性调节与脊髓RI之间相互作用的见解，这可能有助于制定新的康复策略。
This study explored the effect of corticospinal activity on spinal plasticity by examining the interactions between intermittent theta burst transcranial magnetic stimulation (iTBS) of the motor cortex and peripheral patterned electrical stimulation (PES) of the common peroneal nerve (CPN). Healthy volunteers (n = 10) received iTBS to the tibialis anterior (TA) muscle zone of the motor cortex and PES of the CPN in three separate sessions: (1) iTBS-before-PES, (2) iTBS-after-PES, and (3) sham iTBS-before-PES. The PES protocol used 10 100-Hz pulses every 2 s for 20 min. Reciprocal inhibition (RI) from the TA to soleus muscle and motor cortical excitability of the TA and soleus muscles were assessed at baseline, before PES, and 0, 15, 30, and 45 min after PES. When compared to the other protocols, iTBS-before-PES significantly increased changes in disynaptic RI for 15 min and altered long-loop presynaptic inhibition immediately after PES. Moreover, the iTBS-induced cortical excitability changes in the TA before PES were correlated with the enhancement of disynaptic RI immediately after PES. These results demonstrate that spinal plasticity can be modified by altering cortical excitability. This study provides insight into the interactions between modulation of corticospinal excitability and spinal RI, which may help in developing new rehabilitation strategies.
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