Overlapping prefrontal systems involved in cognitive and emotional processing in euthymic bipolar disorder and following sleep deprivation: a review of functional neuroimaging studies.
Overlapping prefrontal systems involved in cognitive and emotional processing in euthymic bipolar disorder and following sleep deprivation: a review of functional neuroimaging studies.
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DOI：
10.1016/j.cpr.2012.07.003
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发表时间：
2012-11
影响因子：
12.8
通讯作者：
Eyler, Lisa T.
中科院分区：
文献类型：
--
作者：
McKenna, Benjamin S.;Eyler, Lisa T.
双相情感障碍患者的前额叶皮层（PFC）介导的认知和情感处理缺陷导致功能限制，即使在情绪稳定期间。睡眠和昼夜节律功能的改变在双相情感障碍中有很好的记录，但很少有研究直接研究睡眠和/或昼夜节律在观察到的认知和情绪处理缺陷中的机制作用。我们系统地回顾了双相情感障碍患者和睡眠剥夺的健康个体的认知和情感处理缺陷依赖于PFC功能。来自两条平行线的研究证据表明，睡眠和昼夜节律可能通过重叠的神经生物学系统参与双相情感障碍中的认知和情感处理缺陷。我们讨论了目前的双极模型，强调PFC边缘连接，并讨论了睡眠相关机制的列入。睡眠和昼夜节律障碍是双相情感障碍的核心特征，神经生物学异常模型应纳入时间生物学措施。进一步研究睡眠和昼夜节律在双相情感障碍的认知和情绪处理中的作用是必要的。
Prefrontal cortex (PFC) mediated cognitive and emotional processing deficits in bipolar disorder lead to functional limitations even during periods of mood stability. Alterations of sleep and circadian functioning are well-documented in bipolar disorder, but there is little research directly examining the mechanistic role of sleep and/or circadian rhythms in the observed cognitive and emotional processing deficits. We systematically review the cognitive and emotional processing deficits reliant upon PFC functioning of euthymic patients with bipolar disorder and in healthy individuals deprived of sleep. The evidence from two parallel lines of investigation suggests that sleep and circadian rhythms may be involved in the cognitive and emotional processing deficits seen in bipolar disorder through overlapping neurobiological systems. We discuss current models of bipolar highlighting the PFC-limbic connections and discuss inclusion of sleep-related mechanisms. Sleep and circadian dysfunction is a core feature of bipolar disorder and models of neurobiological abnormalities should incorporate chronobiological measures. Further research into the role of sleep and circadian rhythms in cognition and emotional processing in bipolar disorder is warranted.
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