SARS-CoV-2 prolonged infection during advanced HIV disease evolves extensive immune escape.
SARS-CoV-2 prolonged infection during advanced HIV disease evolves extensive immune escape.
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DOI：
10.1016/j.chom.2022.01.005
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发表时间：
2022-02-09
影响因子：
30.3
通讯作者：
Sigal A
中科院分区：
文献类型：
--
作者：
Cele S;Karim F;Lustig G;San JE;Hermanus T;Tegally H;Snyman J;Moyo-Gwete T;Wilkinson E;Bernstein M;Khan K;Hwa SH;Tilles SW;Singh L;Giandhari J;Mthabela N;Mazibuko M;Ganga Y;Gosnell BI;Karim SSA;Hanekom W;Van Voorhis WC;Ndung'u T;COMMIT-KZN Team;Lessells RJ;Moore PL;Moosa MS;de Oliveira T;Sigal A
描述特定地区SARS-CoV-2的进化特征可能有助于预测来自这些地区的变体的特性。我们绘制了一种SARS-CoV-2毒株的中和图，该毒株是从南非一名晚期艾滋病毒患者的祖先病毒进化而来的，时间超过6个月；这个人在贝塔和德尔塔变种出现之前就被感染了我们对进化后的病毒进行了纵向追踪，并对其与来自祖先、贝塔病毒和德尔塔病毒感染的自体血浆和恢复期血浆进行了测试。早期的病毒与祖先相似，但它进化出了在欧米克隆和其他变体中发现的大量突变。它显示出大量但不完全的辉瑞BNT162b2逃逸，自身血浆的弱中和，尽管早于Delta，但它也显示出广泛的Delta感染引起的中和逃逸。这个例子与以下观点是一致的：SARS-CoV-2在个体免疫受损的宿主（包括晚期艾滋病毒疾病的宿主）中进化，可能获得疫苗的免疫逃逸和增强的三角洲免疫逃逸，这对疫苗突破和再感染具有影响。进化病毒的血清学关系映射到祖先病毒和关键变体，进化病毒从δ型引发的免疫中逃脱最多，从β型引发的免疫中逃脱最少，进化病毒基本上但不完全逃脱BNT162b2疫苗引发的抗体，Cele等人检查了持续6个月以上的SARS-CoV-2感染。从祖先病毒开始，但在欧米克隆和其他变种中发现了各种突变。进化后的病毒基本上但不完全地逃脱了bnt162b2诱导的免疫以及自身血浆的中和作用，并显示出广泛地逃脱了由Delta感染引起的中和作用。
Characterizing SARS-CoV-2 evolution in specific geographies may help predict properties of the variants that come from these regions. We mapped neutralization of a SARS-CoV-2 strain that evolved over 6 months from ancestral virus in a person with advanced HIV disease in South Africa; this person was infected prior to emergence of the Beta and Delta variants. We longitudinally tracked the evolved virus and tested it against self-plasma and convalescent plasma from ancestral, Beta, and Delta infections. Early virus was similar to ancestral, but it evolved a multitude of mutations found in Omicron and other variants. It showed substantial but incomplete Pfizer BNT162b2 escape, weak neutralization by self-plasma, and despite pre-dating Delta, it also showed extensive escape of Delta infection-elicited neutralization. This example is consistent with the notion that SARS-CoV-2 evolving in individual immune-compromised hosts, including those with advanced HIV disease, may gain immune escape of vaccines and enhanced escape of Delta immunity, and this has implications for vaccine breakthrough and reinfections. An ancestral SARS-CoV-2 infection that persisted over 6 months evolved neutralization escape Evolved virus serological relationship is mapped to ancestral virus and key variants Evolved virus shows greatest escape from Delta-elicited immunity and least from Beta-elicited immunity Evolved virus substantially but incompletely escapes BNT162b2 vaccine-elicited antibodies Cele et al. examine a SARS-CoV-2 infection persisting over 6 months, starting as ancestral virus but evolving various mutations found in Omicron and other variants. The evolved virus substantially but incompletely escaped BNT162b2-elicited immunity as well as neutralization by self-plasma and showed extensive escape from neutralization elicited by Delta infections.
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影响因子：
64.8
作者：
Barnes CO;Jette CA;Abernathy ME;Dam KA;Esswein SR;Gristick HB;Malyutin AG;Sharaf NG;Huey-Tubman KE;Lee YE;Robbiani DF;Nussenzweig MC;West AP Jr;Bjorkman PJ
通讯作者：
Bjorkman PJ
影响因子：
16.6
作者：
Greaney AJ;Starr TN;Barnes CO;Weisblum Y;Schmidt F;Caskey M;Gaebler C;Cho A;Agudelo M;Finkin S;Wang Z;Poston D;Muecksch F;Hatziioannou T;Bieniasz PD;Robbiani DF;Nussenzweig MC;Bjorkman PJ;Bloom JD
通讯作者：
Bloom JD
影响因子：
4.8
作者：
Chen L;Zody MC;Di Germanio C;Martinelli R;Mediavilla JR;Cunningham MH;Composto K;Chow KF;Kordalewska M;Corvelo A;Oschwald DM;Fennessey S;Zetkulic M;Dar S;Kramer Y;Mathema B;Germer S;Stone M;Simmons G;Busch MP;Maniatis T;Perlin DS;Kreiswirth BN
通讯作者：
Kreiswirth BN
影响因子：
64.5
作者：
Garcia-Beltran, Wilfredo F.;Lam, Evan C.;Balazs, Alejandro B.
通讯作者：
Balazs, Alejandro B.
影响因子：
11.8
作者：
Guzman MG;Alvarez M;Rodriguez-Roche R;Bernardo L;Montes T;Vazquez S;Morier L;Alvarez A;Gould EA;Kouri G;Halstead SB
通讯作者：
Halstead SB