Iron deficiency anemia: focus on infectious diseases in lesser developed countries.
Iron deficiency anemia: focus on infectious diseases in lesser developed countries.
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作者：
Shaw JG;Friedman JF
缺铁性贫血被认为影响全世界10亿多人的健康，欠发达国家的疾病负担最重，特别是育龄妇女和儿童。这种更大的疾病负担是由于营养和传染病的原因造成的。在欠发达国家，人们的饮食中铁的含量要低得多，幼儿和孕妇获得复合维生素的机会较少，而生育率的提高增加了一生中对铁的需求。传染病，特别是寄生虫病，也会导致体外铁流失和炎症性贫血，从而降低铁对宿主组织的生物利用度。本文将讨论缺铁性贫血的独特病因和后果，以及炎症性贫血中铁的吸收和分布的改变。在这种独特的情况下，诊断和治疗的意义也将被讨论。
Iron deficiency anemia is thought to affect the health of more than one billion people worldwide, with the greatest burden of disease experienced in lesser developed countries, particularly women of reproductive age and children. This greater disease burden is due to both nutritional and infectious etiologies. Individuals in lesser developed countries have diets that are much lower in iron, less access to multivitamins for young children and pregnant women, and increased rates of fertility which increase demands for iron through the life course. Infectious diseases, particularly parasitic diseases, also lead to both extracorporeal iron loss and anemia of inflammation, which decreases bioavailability of iron to host tissues. This paper will address the unique etiologies and consequences of both iron deficiency anemia and the alterations in iron absorption and distribution seen in the context of anemia of inflammation. Implications for diagnosis and treatment in this unique context will also be discussed.
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影响因子：
4.2
作者：
Antelman, G;Msamanga, GI;Fawzi, WW
通讯作者：
Fawzi, WW
DOI：
10.4269/ajtmh.2005.72.540
发表时间：
2005-05-01
影响因子：
3.3
作者：
Ezeamama, AE;Friedman, JF;McGarvey, ST
通讯作者：
McGarvey, ST
影响因子：
15.8
作者：
Dellicour, Stephanie;Tatem, Andrew J.;ter Kuile, Feiko O.
通讯作者：
ter Kuile, Feiko O.
影响因子：
3.3
作者：
Beasley, NMR;Tomkins, AM;Bundy, DAP
通讯作者：
Bundy, DAP
影响因子：
2.4
作者：
Crompton, DWT
通讯作者：
Crompton, DWT