Diaphragmatic function during hypercapnia: neonatal and developmental aspects.
Diaphragmatic function during hypercapnia: neonatal and developmental aspects.
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高碳酸血症期间的膈肌功能：新生儿和发育方面。
DOI：
10.1152/jappl.1987.62.2.768
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Woodrum,DE
中科院分区：
文献类型：
--
作者：
Watchko,JF;Standaert,TA;Woodrum,DE
研究了急性高碳酸血症对6只自主呼吸麻醉仔猪（4 ~ 8 d）和6只麻醉仔猪（16 ~ 20 d）膈肌力输出的影响。通过分析膈神经刺激时产生的横膈膜压力（Pdi）来评估膈肌力输出。在基线条件下（50% O2 - 50% N2）和呼吸5%、10%或15% CO2与N2和50% O2平衡引起的高碳酸血症10分钟后测量Pdi。在10%和15%高碳酸血症条件下，仔猪Pdi显著低于基线（P < 0.05），而大龄仔猪Pdi则不显著低于基线。15% CO2高碳酸血症时，呼气末肺容量减少。在较低的呼气末肺容量时，力输出增加发生在老年仔猪身上，且与年轻仔猪相比显著增加（P < 0.05）。当校正肺容量对Pdi的影响时，对15% CO2高碳酸血症的反应没有年龄相关的差异。我们得出结论，严重的高碳酸血症对幼崽和大龄仔猪的膈肌力输出都有抑制作用，并且幼崽和大龄仔猪在呼气末肺容量较低时膈肌力输出增益的增加存在差异，且越成熟的仔猪膈肌力输出越大。
The effect of acute hypercapnia on diaphragmatic force output was studied in 6 young (4–8 days) and 6 older (16–20 days) anesthetized, spontaneously breathing piglets. Diaphragmatic force output was assessed by analysis of the transdiaphragmatic pressure (Pdi) generated during phrenic nerve stimulation. Pdi was measured under base-line conditions (50% O2–50% N2) and after 10 min of hypercapnia induced by breathing 5, 10, or 15% CO2 balanced with N2 and 50% O2. Pdi was significantly less than base line during the 10 and 15% hypercapnic conditions in the young (P less than 0.05) but not the older piglets. End-expiratory lung volume was noted to decrease during 15% CO2 hypercapnia. Force output augmentation occurred at this lower end-expiratory lung volume and was significantly greater in the older piglet compared with its younger counterpart (P less than 0.05). When the effects of lung volume on Pdi were corrected for, there was no age-related difference in the response to 15% CO2 hypercapnia. We conclude that severe hypercapnia has a depressant effect on diaphragmatic force output in both young and older piglets, and a differential augmentation in diaphragmatic force-output gain occurs at lower end-expiratory lung volume between young and older piglets, with the greater output occurring in the more mature animal.
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