Conversion of calcium-l-methylfolate and (6S)-5-methyltetrahydrofolic acid glucosamine salt into dietary folate equivalents.
Conversion of calcium-l-methylfolate and (6S)-5-methyltetrahydrofolic acid glucosamine salt into dietary folate equivalents.
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DOI：
10.2903/j.efsa.2022.7452
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发表时间：
2022-08
期刊：
影响因子：
3.3
通讯作者：
Pentieva, Kristina
中科院分区：
文献类型：
--
作者：
Turck, Dominique;Bohn, Torsten;Castenmiller, Jacqueline;De Henauw, Stefaan;Hirsch-Ernst, Karen Ildico;Knutsen, Helle Katrine;Maciuk, Alexandre;Mangelsdorf, Inge;McArdle, Harry J.;Naska, Androniki;Pelaez, Carmen;Siani, Alfonso;Thies, Frank;Tsabouri, Sophia;Vinceti, Marco;Cubadda, Francesco;Abrahantes, Jose Cortinas;Dumas, Celine;Ercolano, Valeria;Titz, Ariane;Pentieva, Kristina
关键词：
应欧盟委员会的要求，欧洲食品安全局营养、新型食品和食物过敏原小组(NDA)被要求就叶酸钙-L-甲基叶酸钙和(6S)-5-甲基四氢叶酸氨基葡萄糖盐(以下统称为5-MTHF)转化为膳食叶酸当量(DFE)发表科学意见。在系统回顾之后，该意见的结论是基于一项成人摄入量和 400 μg/天的干预研究和三项成人摄入量≥ 400 μg/天的干预研究。在每日摄入量低于400MTHF时，叶酸(FA)被认为与摄入量和状态的生物标志物的反应呈线性相关，是推导5- μ的DFE转换系数的合适比较指标。建议使用与叶酸相同的因子将5-甲基四氢呋喃转化为DFE，用于摄入量和 400 μg/天。由于这种摄入量不太可能通过强化食品摄入而超过，相对于天然食品叶酸(NF)的1.7换算系数可适用于添加到食品中的5-甲基四氢呋喃和每天提供400 μg的食品补充剂。在400 μg/天时，5-甲基四氢呋喃的生物利用度比叶酸更高，对于这个摄入量和更高的摄入量，建议转换系数为2。对于强化食品和提供摄入量的食品补充剂，推导出的DFE方程为：DFE = NF + 1.7 × FA + 1.7 × 5-MTHF； 400 μg/天；以及DFE = NF + 1.7 × FA + 2.0 × 5-MTHF，提供≥ 400 μg/天。虽然这一评估适用于L-甲基叶酸钙和5-MTHF氨基葡萄糖盐，但认为阳离子对生物利用度的影响可能在所提出的DFE方程的误差范围内。因此，所提出的方程也适用于与其他阳离子缔合的5-MTHF。
Following a request from the European Commission, the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to deliver a scientific opinion on the conversion of calcium‐l‐methylfolate and (6S)‐5‐methyltetrahydrofolic acid glucosamine salt (collectively called 5‐MTHF hereafter) into dietary folate equivalents (DFE). Following a systematic review, the conclusions of the opinion are based on one intervention study in adults for intakes < 400 μg/day and three intervention studies in adults for intakes ≥ 400 μg/day. At intakes below 400 μg/day, folic acid (FA) is assumed to be linearly related to responses of biomarkers of intake and status and is an appropriate comparator for deriving a DFE conversion factor for 5‐MTHF. It is proposed to use the same factor as for folic acid for conversion of 5‐MTHF into DFE for intakes < 400 μg/day. As such intake levels are unlikely to be exceeded through fortified food consumption, the conversion factor of 1.7 relative to natural food folate (NF) could be applied to 5‐MTHF added to foods and to food supplements providing < 400 μg/day. At 400 μg/day, 5‐MTHF was found to be more bioavailable than folic acid and a conversion factor of 2 is proposed for this intake level and for higher intakes. The derived DFE equations are DFE = NF + 1.7 × FA + 1.7 × 5‐MTHF for fortified foods and food supplements providing intakes < 400 μg/day; and DFE = NF + 1.7 × FA + 2.0 × 5‐MTHF for food supplements providing intakes ≥ 400 μg/day. Although this assessment applies to calcium‐L‐methylfolate and 5‐MTHF glucosamine salt, it is considered that the influence of the cation on bioavailability is likely to be within the margin of error of the proposed DFE equations. Therefore, the proposed equations can also be applied to 5‐MTHF associated with other cations.
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影响因子：
1.7
作者：
Bayes, Jessica;Agrawal, Nitish;Schloss, Janet
通讯作者：
Schloss, Janet
DOI：
10.1152/ajpregu.1995.269.3.r490
发表时间：
1995-09-01
影响因子：
2.8
作者：
CASIROLA, DM;VINNAKOTA, RR;FERRARIS, RP
通讯作者：
FERRARIS, RP
影响因子：
4.2
作者：
Gregory, JF
通讯作者：
Gregory, JF
影响因子：
4.7
作者：
Akoglu, B.;Schrott, M.;Faust, D.
通讯作者：
Faust, D.
影响因子：
4.2
作者：
BHANDARI, SD;GREGORY, JF
通讯作者：
GREGORY, JF