Termination of transcription and its regulation in the tryptophan operon of E. coli

Termination of transcription and its regulation in the tryptophan operon of E. coli
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大肠杆菌色氨酸操纵子的转录终止及其调控

DOI:
10.1016/0092-8674(81)90496-7
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发表时间:
1981
期刊:
影响因子:
64.5
通讯作者:
T. Platt
T. Platt
中科院分区:
生物学1区
文献类型:
--
作者:
T. Platt

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转录终止作为控制基因表达的一种重要而有力的机制正在出现,这是四个非常不同领域的研究证据汇聚的结果。首先,遗传学的方法来理解监管机制,导致发现和表征的特定蛋白质因子,影响终止和antitermination。第二,研究表明翻译极性现象是由于转录的提前终止。第三,对基因簇之前的衰减子位点的鉴定和分析表明,基因表达的程度可以通过终止来调节,而与启动子/操纵基因的调节无关。最后,最近的研究结果表明,终止区的结构和功能可能比以前设想的更复杂。
Termination of transcription is emerging as an important and powerful mechanism for controlling gene expression as the result of converging evidence from studies in four very different areas. First, genetic approaches to understanding regulatory mechanisms have led to the discovery of and characterization of specific protein factors that effect termination and antitermination. Second, studies suggest that the phenomenon of translational polarity is due to premature termination of transcription. Third, the identification and analysis of attenuator sites preceding gene clusters has demonstrated that the extent of gene expression can be modulated by termination, independent of promoter/operator regulation. Finally, recent results concerning termination at the end of genes or operons indicate that the structure and function of termination regions may be more complex than previously envisioned.
大肠杆菌 trp mRNA 衰变过程中信息之间随机核酸内切裂解的证据。
DOI: 10.1016/0022-2836(80)90388-5
发表时间: 1980
影响因子: 5.6
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通讯作者: Kennell,D
DOI: --
发表时间: 1980
期刊: The Journal of biological chemistry
影响因子: --
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