Paracrine regulation of insulin secretion.
Paracrine regulation of insulin secretion.
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DOI：
10.1007/s00125-020-05213-5
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发表时间：
2020-10
期刊：
影响因子：
8.2
通讯作者：
Huising MO
中科院分区：
文献类型：
--
作者：
Huising MO
胰腺β细胞是我们身体中唯一能够产生和分泌胰岛素的细胞类型，以指导我们身体的胰岛素敏感细胞和组织在餐后吸收营养。准确控制胰岛素的释放至关重要;胰岛素过少会导致糖尿病，而过量的胰岛素可能会导致潜在的致命性低血糖。然而，大多数人的胰腺将在几十年内安全有效地控制胰岛素分泌，并对成千上万次膳食引起的葡萄糖波动做出反应。因为我们只有在胰腺无法维持葡萄糖稳态时才意识到胰腺的重要贡献，所以很容易忘记健康胰腺的胰岛素释放与胰岛素需求的匹配程度，以确保稳定的血糖。β细胞通过与胰岛中其他内分泌细胞类型的广泛串扰来实现这一壮举，特别是产生胰高血糖素的α细胞和产生生长抑素的δ细胞。在这里，我将审查的重要旁分泌的贡献，这些细胞中的每一个作出的刺激和随后的抑制胰岛素释放响应于一个短暂的营养刺激，并作出的情况下，这种局部串扰的故障有助于糖尿病的病理生理。关于调节胰岛素和胰高血糖素分泌的α、β和δ细胞之间胰岛内旁分泌串扰的新综述，来自加州大学戴维斯分校的Mark Huising @Huisinglab #diabetes #somatostatin #crosstalk
Pancreatic beta cells are the only cell type in our body capable of producing and secreting insulin to instruct the insulin-sensitive cells and tissues of our bodies to absorb nutrients after a meal. Accurate control of insulin release is of critical importance; too little insulin leads to diabetes, while an excess of insulin can cause potentially fatal hypoglycemia. Yet, the pancreas of most people will control insulin secretion safely and effectively over decades and in response to glucose excursions driven by tens of thousands of meals. Because we only become aware of the important contributions of the pancreas when it fails to maintain glucose homeostasis, it is easy to forget just how well insulin release from a healthy pancreas is matched to insulin need to ensure stable glycemia. Beta cells achieve this feat by extensive crosstalk with the rest of the endocrine cell types in the islet, notably the glucagon-producing alpha cells and somatostatin-producing delta cells. Here I will review the important paracrine contributions that each of these cells makes to the stimulation and subsequent inhibition of insulin release in response to a transient nutrient stimulation, and make the case that a breakdown of this local crosstalk contributes to the pathophysiology of diabetes. New review on the paracrine crosstalk within the pancreatic islet between alpha, beta, and delta cells that regulates insulin and glucagon secretion by Mark Huising from the University of California Davis @Huisinglab #diabetes #somatostatin #crosstalk
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影响因子：
8.2
作者：
Hogan MF;Hull RL
通讯作者：
Hull RL
影响因子：
8
作者：
Capozzi, Megan E.;Wait, Jacob B.;Campbell, Jonathan E.
通讯作者：
Campbell, Jonathan E.
DOI：
10.1007/s00109-020-01887-x
发表时间：
2020-04
期刊：
Journal of molecular medicine (Berlin, Germany)
影响因子：
--
作者：
Hartig SM;Cox AR
通讯作者：
Cox AR
影响因子：
7
作者：
Lawlor N;George J;Bolisetty M;Kursawe R;Sun L;Sivakamasundari V;Kycia I;Robson P;Stitzel ML
通讯作者：
Stitzel ML
影响因子：
29
作者：
Chambers AP;Sorrell JE;Haller A;Roelofs K;Hutch CR;Kim KS;Gutierrez-Aguilar R;Li B;Drucker DJ;D'Alessio DA;Seeley RJ;Sandoval DA
通讯作者：
Sandoval DA