The islet endothelial cell: a novel contributor to beta cell secretory dysfunction in diabetes.
The islet endothelial cell: a novel contributor to beta cell secretory dysfunction in diabetes.
复制标题
DOI：
10.1007/s00125-017-4272-9
复制
发表时间：
2017-06
期刊：
影响因子：
8.2
通讯作者：
Hull RL
中科院分区：
文献类型：
--
作者：
Hogan MF;Hull RL
胰岛高度血管化，具有广泛的毛细血管网。除了为胰岛内分泌细胞提供营养和氧气并将激素输送到外周循环外，胰岛毛细血管（主要由胰岛内皮细胞组成）是增强胰岛β细胞存活和功能的重要信号来源。在2型糖尿病及其动物模型中，有证据表明这些胰岛内皮细胞中存在形态和功能异常。在糖尿病中，胰岛毛细血管增厚、扩张和破碎，并且胰岛内皮细胞表达炎症和活化的标志物。体外数据表明，这种功能障碍的胰岛内皮细胞表型可能导致β细胞胰岛素释放受损。本文综述了可能介导胰岛内皮细胞在正常条件下对β细胞存活和功能的积极作用的潜在候选分子。此外，它还探讨了糖尿病胰岛内皮功能障碍的可能机制，并回顾了改善2型糖尿病胰岛病变的治疗方案。最后，考虑人类和啮齿动物胰岛血管系统之间的差异和潜在的不可预见的负面后果的策略，以扩大胰岛血管系统，特别是在糖尿病条件下，进行了讨论。
The pancreatic islet is highly vascularised, with an extensive capillary network. In addition to providing nutrients and oxygen to islet endocrine cells and transporting hormones to the peripheral circulation, islet capillaries (comprised primarily of islet endothelial cells) are an important source of signals that enhance survival and function of the islet beta cell. In type 2 diabetes, and animal models thereof, evidence exists of morphological and functional abnormalities in these islet endothelial cells. In diabetes, islet capillaries are thickened, dilated and fragmented, and islet endothelial cells express markers of inflammation and activation. In vitro data suggests that this dysfunctional islet endothelial phenotype may contribute to impaired insulin release from the beta cell. This review examines potential candidate molecules that may mediate the positive effects of islet endothelial cells on beta cell survival and function under normal conditions. Further, it explores possible mechanisms underlying the development of islet endothelial dysfunction in diabetes and reviews therapeutic options for ameliorating this aspect of the islet lesion in type 2 diabetes. Finally, considerations regarding differences between human and rodent islet vasculature and the potentially unforeseen negative consequences of strategies to expand the islet vasculature, particularly under diabetic conditions, are discussed.
登录
查看更多内容
2型糖尿病中内分泌 - 分泌胰腺传播的衰减：胰腺外基质基质超微结构异常。
DOI：
10.1111/j.1559-4572.2008.00024.x
发表时间：
2008
期刊：
Journal of the cardiometabolic syndrome
影响因子：
--
作者：
Hayden MR;Patel K;Habibi J;Gupta D;Tekwani SS;Whaley-Connell A;Sowers JR
通讯作者：
Sowers JR
影响因子：
3.2
作者：
Jiang, FX;Naselli, G;Harrison, LC
通讯作者：
Harrison, LC
影响因子：
5.8
作者：
Carlsson, PO;Palm, F;Mattsson, G
通讯作者：
Mattsson, G
影响因子：
4.8
作者：
Johansson, M;Mattsson, G;Carlsson, PO
通讯作者：
Carlsson, PO
影响因子：
3.7
作者：
Drott CJ;Olerud J;Emanuelsson H;Christoffersson G;Carlsson PO
通讯作者：
Carlsson PO