Gold nanocages: from synthesis to theranostic applications.
Gold nanocages: from synthesis to theranostic applications.
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DOI：
10.1021/ar200061q
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发表时间：
2011-10-18
影响因子：
18.3
通讯作者：
Brown, Paige K.
中科院分区：
文献类型：
--
作者：
Xia, Younan;Li, Weiyang;Cobley, Claire M.;Chen, Jingyi;Xia, Xiaohu;Zhang, Qiang;Yang, Miaoxin;Cho, Eun Chul;Brown, Paige K.
近年来，金纳米结构因其有利的化学和物理性质而具有增强癌症诊断和治疗的潜力而受到相当大的关注。Au纳米结构的关键特征是其具有吸引力的光学性质，即由于等离子体激元振荡的激发而在共振波长处对光的散射和吸收。这种现象通常被称为局部表面等离子体共振（LSPR），并且是常规Au胶体的红宝石色的来源。共振波长高度依赖于纳米结构的尺寸、形状和几何形状，提供了一组旋钮来根据需要操纵光学性质。对于体内应用，特别是当涉及光学激发或转导时，必须将Au纳米结构的LSPR峰调谐到近红外（NIR）区域（700-900 nm）中的软组织的透明窗口，以使穿透深度最大化。在NIR区域中具有可调LSPR峰的一类纳米结构是Au纳米笼。这些多功能的纳米结构的特征在于中空的内部，多孔和多孔壁，并且可以使用基于Ag纳米立方体和氯金酸水溶液之间的电置换的非常简单的程序以相对大量地制备。Au纳米笼的LSPR峰可以通过控制它们的尺寸和/或壁厚容易且精确地调谐到NIR区域中的任何波长。Au纳米笼的其他重要特征使其成为生物医学应用的特别有趣的材料，包括其紧凑的尺寸，大的吸收截面（比常规有机染料的吸收截面大近五个数量级），生物惰性，以及基于Au-硫醇盐化学的表面改性的稳健和直接的程序。在这篇文章中，我们介绍了Au纳米笼在治疗诊断领域的一些最新进展，包括它们的用途：i）作为多光子发光追踪的示踪剂; ii）作为光声（PA）和多模态成像的造影剂。（PA/荧光）成像; iii）作为光热剂用于选择性破坏癌性或患病组织;和iv）作为药物递送载体，用于响应于外部刺激如NIR辐射或高强度聚焦超声（HIFU）的受控和局部释放。
Gold nanostructures have garnered considerable attention in recent years for their potential to enhance both the diagnosis and treatment of cancer through their advantageous chemical and physical properties. The key feature of Au nanostructures for enabling this diverse array of biomedical applications is their attractive optical properties, i.e. the scattering and absorption of light at resonant wavelengths due to the excitation of plasmon oscillations. This phenomenon is commonly known as localized surface plasmon resonance (LSPR) and is the source of the ruby red color of conventional Au colloids. The resonant wavelength is highly dependent on the size, shape, and geometry of the nanostructures, providing a set of knobs to maneuver the optical properties as needed. For in vivo applications, especially when optical excitation or transduction is involved, the LSPR peaks of the Au nanostructures have to be tuned to the transparent window of soft tissues in the near-infrared (NIR) region (from 700–900 nm) in order to maximize the penetration depth. One class of nanostructures with tunable LSPR peaks in the NIR region is Au nanocages. These versatile nanostructures are characterized by hollow interiors, ultrathin and porous walls, and can be prepared in relatively large quantities using a remarkably simple procedure based on the galvanic replacement between Ag nanocubes and aqueous chloroauric acid. The LSPR peaks of Au nanocages can be readily and precisely tuned to any wavelength in the NIR region by controlling their size and/or wall thickness. Other significant features of Au nanocages that make them particularly intriguing materials for biomedical applications include their compact sizes, large absorption cross sections (almost five orders of magnitude greater than those of conventional organic dyes), bio-inertness, as well as a robust and straightforward procedure for surface modification based on the Au-thiolate chemistry. In this article, we present some of the most recent advances in the use of Au nanocages for a broad range of theranostic applications, including their use: i) as tracers for tracking by multi-photon luminescence; ii) as contrast agents for photoacoustic (PA) and mutimodal (PA/fluorescence) imaging; iii) as photothermal agents for the selective destruction of cancerous or diseased tissue; and iv) as drug delivery vehicles for controlled and localized release in response to external stimuli such as NIR radiation or high-intensity focused ultrasound (HIFU).
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影响因子：
17.1
作者：
Ma Y;Li W;Cho EC;Li Z;Yu T;Zeng J;Xie Z;Xia Y
通讯作者：
Xia Y
影响因子：
19
作者：
Chen J;Yang M;Zhang Q;Cho EC;Cobley CM;Kim C;Glaus C;Wang LV;Welch MJ;Xia Y
通讯作者：
Xia Y
影响因子：
15
作者：
Moon, Geon Dae;Choi, Sung-Wook;Cai, Xin;Li, Weiyang;Cho, Eun Chul;Jeong, Unyong;Wang, Lihong V.;Xia, Younan
通讯作者：
Xia, Younan
影响因子：
10.8
作者：
Sun, YG;Mayers, BT;Xia, YN
通讯作者：
Xia, YN
影响因子：
17.1
作者：
Au L;Zhang Q;Cobley CM;Gidding M;Schwartz AG;Chen J;Xia Y
通讯作者：
Xia Y