A new theranostic system based on gold nanocages and phase-change materials with unique features for photoacoustic imaging and controlled release.
A new theranostic system based on gold nanocages and phase-change materials with unique features for photoacoustic imaging and controlled release.
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DOI：
10.1021/ja200894u
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发表时间：
2011-04-06
影响因子：
15
通讯作者：
Xia, Younan
中科院分区：
文献类型：
--
作者：
Moon, Geon Dae;Choi, Sung-Wook;Cai, Xin;Li, Weiyang;Cho, Eun Chul;Jeong, Unyong;Wang, Lihong V.;Xia, Younan
该通信报告了一种新的治疗诊断系统，该系统具有增强光声（PA）成像对比度和通过高强度聚焦超声（HIFU）控制化学或生物效应器释放的能力。该系统的制造简单地涉及用相变材料（PCM）例如熔点为38-39 °C的1-十四醇填充金纳米笼的中空内部。PCM可以被预混合并且因此装载有染料以及其他化学或生物效应物。当暴露于直接加热或HIFU时，PCM将熔化并通过表面上的小孔从纳米笼的内部逸出，同时将封装的分子释放到周围介质中。我们可以通过改变HIFU的功率、暴露于HIFU的持续时间或两者来控制释放曲线。
This communication reports a new theranostic system with a combination of capabilities to both enhance the contrast of photoacoustic (PA) imaging and control the release of a chemical or biological effecter by high-intensity focused ultrasound (HIFU). The fabrication of this system simply involves filling the hollow interiors of gold nanocages with a phase-change material (PCM) such as 1-tetradecanol that has a melting point of 38–39 °C. The PCM can be pre-mixed and thus loaded with a dye, as well as other chemical or biological effecters. When exposed to direct heating or HIFU, the PCM will melt and escape from the interiors of nanocages through small pores on the surface, concurrently releasing the encapsulated molecules into the surrounding medium. We can control the release profile by varying the power of HIFU, the duration of exposure to HIFU, or both.
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影响因子：
16.6
作者：
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通讯作者：
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