Bone repair cells for craniofacial regeneration.
Bone repair cells for craniofacial regeneration.
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DOI：
10.1016/j.addr.2012.03.005
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发表时间：
2012-09
影响因子：
16.1
通讯作者：
Giannobile, W. V.
中科院分区：
文献类型：
--
作者：
Pagni, G.;Kaigler, D.;Rasperini, G.;Avila-Ortiz, G.;Bartel, R.;Giannobile, W. V.
复杂颅面畸形的重建是损伤、先天性缺陷或疾病情况下的临床挑战。细胞疗法的使用代表了增强颅面伤口愈合再生反应的最先进方法之一。体细胞和干细胞都已被用于复杂骨缺损的治疗，并且在寻找最合适的支架以提供人类再生医学中的细胞疗法方面取得了进展。作为颅面再生临床应用方法的一个例子，Ixmyelocel-T或骨修复细胞是骨髓衍生干细胞和祖细胞的来源。它们是通过使用CD90+间充质干细胞和CD14+单核细胞/巨噬细胞祖细胞的单次灌注生物反应器生产的。ixmyelocel-T在肌肉、血管、神经和骨组织再生方面的应用已显示出潜力。本文的目的是强调细胞疗法用于修复骨和软组织缺损在口腔和颅面复合体。这一领域目前仍处于早期阶段，但这一综述将为细胞疗法最终进入临床实践提供深入的见解。
Reconstruction of complex craniofacial deformities is a clinical challenge in situations of injury, congenital defects or disease. The use of cell-based therapies represents one of the most advanced methods for enhancing the regenerative response for craniofacial wound healing. Both Somatic and Stem Cells have been adopted in the treatment of complex osseous defects and advances have been made in finding the most adequate scaffold for the delivery of cell therapies in human regenerative medicine. As an example of such approaches for clinical application for craniofacial regeneration, Ixmyelocel-T or bone repair cells are a source of bone marrow derived stem and progenitor cells. They are produced through the use of single pass perfusion bioreactors for CD90+ mesenchymal stem cells and CD14+ monocyte/macrophage progenitor cells. The application of ixmyelocel-T has shown potential in the regeneration of muscular, vascular, nervous and osseous tissue. The purpose of this manuscript is to highlight cell therapies used to repair bony and soft tissue defects in the oral and craniofacial complex. The field at this point remains at an early stage, however this review will provide insights into the progress being made using cell therapies for eventual development into clinical practice.
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影响因子：
2.6
作者：
Boiret, N;Rapatel, C;Berger, MG
通讯作者：
Berger, MG
DOI：
10.1016/s0901-5027(06)80085-8
发表时间：
1995-04-01
影响因子：
2.4
作者：
COHEN, MM
通讯作者：
COHEN, MM
影响因子：
1.5
作者：
Breitbart, AS;Grande, DA;Grant, RT
通讯作者：
Grant, RT
影响因子：
2.6
作者：
Bachier, CR;Gokmen, E;LeMaistre, CF
通讯作者：
LeMaistre, CF
影响因子：
2.4
作者：
Cerruti, Humberto Filho;Kerkis, Irina;Pereira da Silva, Marcelo Cavenaghi
通讯作者：
Pereira da Silva, Marcelo Cavenaghi