Serum RANKL levels in Chinese patients with ankylosing spondylitis: a meta-analysis.
Serum RANKL levels in Chinese patients with ankylosing spondylitis: a meta-analysis.
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中国强直性脊柱炎患者血清RANKL水平：一项荟萃分析
DOI：
10.1186/s13018-021-02721-x
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发表时间：
2021-10-18
影响因子：
2.6
通讯作者：
Li J
中科院分区：
文献类型：
--
作者：
Ni F;Zhang Y;Peng Y;Peng X;Li J
我们旨在确定中国患者血清核因子 - κB受体活化因子配体（sRANKL）水平与强直性脊柱炎（AS）之间的关联。
检索了PubMed、Cochrane图书馆、Embase、中国生物医学文献数据库、Web of Science、中国知网、维普和万方数据库中2020年10月1日之前发表的研究，无语言限制。使用STATA 12.0版和Revman 5.3版对数据进行分析。计算了标准化均数差（SMD）和相应的95%置信区间（95% CI）。
纳入了12项临床病例对照研究，包括585例AS患者和423例健康对照。sRANKL的合并SMD表明，中国AS患者的sRANKL水平显著高于健康对照（SMD：3.27，95% CI 2.11 - 4.43，P < 0.00001）。中国AS患者血清RANKL相关因子骨保护素（OPG）水平（SMD：0.86，95% CI 0.09 - 1.64，P < 0.03）低于健康对照，中国AS患者的RANKL/OPG比值（SMD = 1.05，95% CI 0.64 - 1.46，P < 0.00001）与健康对照大致相同。亚组分析表明，中国南方和北方的患者sRANKL水平均高于对照组；在中国南方患者中，巴斯强直性脊柱炎功能指数（BASFI）> 4的亚组患者sRANKL水平高于其他亚组患者。就病程而言，患病> 8年的AS患者sRANKL水平高于健康对照组。还按地区、语言、对照组来源、年龄和巴斯强直性脊柱炎疾病活动指数（BASDAI）进行了其他亚组分析。在这些亚组中，AS患者的sRANKL水平显著高于健康对照组。BASFI和BASDAI是异质性的来源。
中国AS患者的sRANKL水平较高，尤其是中国南方患者。sRANKL水平可能与中国患者AS的发病机制呈正相关。
We aimed to determine the association between serum receptor activator of nuclear factor-kappa B ligand (sRANKL) levels and ankylosing spondylitis (AS) in Chinese patients. The PubMed, Cochrane Library, Embase, Chinese Biomedical Database, Web of Science, China National Knowledge Infrastructure, VIP, and Wan Fang databases were searched for studies conducted before October 1, 2020, without language restrictions. STATA version 12.0 and Revman version 5.3 were used to analyze the data. The standard mean differences (SMDs) and corresponding 95% confidence intervals (95% CIs) were calculated. Twelve clinical case–control studies, including 585 patients with AS and 423 healthy controls, were included. The combined SMD for sRANKL suggested that the sRANKL level was significantly higher in Chinese patients with AS than in healthy controls (SMD: 3.27, 95% CI 2.11–4.43, P < 0.00001). Serum RANKL-related factor osteoprotegerin (OPG) levels (SMD: 0.86, 95% CI 0.09–1.64, P < 0.03) were lower in the Chinese patients with AS than in healthy controls, and the RANKL/OPG ratio (SMD = 1.05, 95% CI 0.64–1.46, P < 0.00001) in Chinese patients with AS was approximately the same as that of healthy controls. Subgroup analysis indicated that patients from North and South China had higher sRANKL levels than controls; the sRANKL levels of patients from South China were higher in the subgroup with a Bath Ankylosing Spondylitis Functional Index (BASFI) of > 4 than those of patients in other subgroups. In terms of duration, patients with AS for > 8 years had higher sRANKL levels than health controls. Other subgroup analyses were conducted by region, language, source of control, age, and Bath Ankylosing Spondylitis Disease Activity Index (BASDAI). In these subgroups, the sRANKL levels were significantly higher in the patients with AS than in healthy controls. The BASFI and BASDAI were sources of heterogeneity. The sRANKL levels are higher in Chinese patients with AS, especially among those from South China. sRANKL levels may be positively correlated with the pathogenesis of AS among Chinese patients.
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