Proceedings of the fifth international Molecular Pathological Epidemiology (MPE) meeting.
Proceedings of the fifth international Molecular Pathological Epidemiology (MPE) meeting.
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DOI：
10.1007/s10552-022-01594-7
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发表时间：
2022-08
影响因子：
2.3
通讯作者：
Ogino, Shuji
中科院分区：
文献类型：
--
作者：
Yao, Song;Campbell, Peter T.;Ugai, Tomotaka;Gierach, Gretchen;Abubakar, Mustapha;Adalsteinsson, Viktor;Almeida, Jonas;Brennan, Paul;Chanock, Stephen;Golub, Todd;Hanash, Samir;Harris, Curtis;Hathaway, Cassandra A.;Kelsey, Karl;Landi, Maria Teresa;Mahmood, Faisal;Newton, Christina;Quackenbush, John;Rodig, Scott;Schultz, Nikolaus;Tearney, Guillermo;Tworoger, Shelley S.;Wang, Molin;Zhang, Xuehong;Garcia-Closas, Montserrat;Rebbeck, Timothy R.;Ambrosone, Christine B.;Ogino, Shuji
关键词：
癌症异质性是深入了解癌症病因和进展以及发现更精确的癌症治疗方法的关键。现代病理学和分子技术提供了一套强大的工具，可以在大量患者人群中从DNA到RNA，蛋白质和表观遗传学，以及从肿瘤组织到肿瘤微环境和液体活检的多个水平上描述肿瘤异质性。当与经过充分验证的流行病学方法学和良好表征的流行病学资源相结合时，丰富的肿瘤病理学和分子肿瘤信息以前所未有的广度和深度提供了新的研究机会。这是分子病理流行病学（MPE）十多年前出现的研究领域，自那时以来一直蓬勃发展。作为一个真正的多学科领域，MPE包含来自不同领域的合作，包括流行病学，病理学，免疫学，遗传学，生物统计学，生物信息学和数据科学。自2013年首次召开以来，国际MPE会议系列已发展成为一个充满活力的专用平台，供这些学科的专家交流新的发现，讨论新的研究机会和挑战，建立专业网络，并教育下一代科学家。在此，我们分享了2021年5月24日和25日在线举行的第五届国际MPE会议的会议记录。会议由21个演讲组成，分为三个主题，即最近的综合MPE研究，新型癌症分析技术以及新的统计和数据科学方法。展望不久的将来，与会者预计MPE研究将在许多研究领域不断扩大和取得成果，特别是免疫流行病学，突变特征，液体活检和健康差异。
Cancer heterogeneities hold the key to a deeper understanding of cancer etiology and progression and the discovery of more precise cancer therapy. Modern pathological and molecular technologies offer a powerful set of tools to profile tumor heterogeneities at multiple levels in large patient populations, from DNA to RNA, protein and epigenetics, and from tumor tissues to tumor microenvironment and liquid biopsy. When coupled with well-validated epidemiologic methodology and well-characterized epidemiologic resources, the rich tumor pathological and molecular tumor information provide new research opportunities at an unprecedented breadth and depth. This is the research space where Molecular Pathological Epidemiology (MPE) emerged over a decade ago and has been thriving since then. As a truly multidisciplinary field, MPE embraces collaborations from diverse fields including epidemiology, pathology, immunology, genetics, biostatistics, bioinformatics, and data science. Since first convened in 2013, the International MPE Meeting series has grown into a dynamic and dedicated platform for experts from these disciplines to communicate novel findings, discuss new research opportunities and challenges, build professional networks, and educate the next-generation scientists. Herein, we share the proceedings of the Fifth International MPE meeting, held virtually online, on May 24 and 25, 2021. The meeting consisted of 21 presentations organized into the three main themes, which were recent integrative MPE studies, novel cancer profiling technologies, and new statistical and data science approaches. Looking forward to the near future, the meeting attendees anticipated continuous expansion and fruition of MPE research in many research fronts, particularly immune-epidemiology, mutational signatures, liquid biopsy, and health disparities.
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影响因子：
5.1
作者：
Dai J;Nishi A;Tran N;Yamamoto Y;Dewey G;Ugai T;Ogino S
通讯作者：
Ogino S
影响因子：
29.4
作者：
Cao Y;Nishihara R;Qian ZR;Song M;Mima K;Inamura K;Nowak JA;Drew DA;Lochhead P;Nosho K;Morikawa T;Zhang X;Wu K;Wang M;Garrett WS;Giovannucci EL;Fuchs CS;Chan AT;Ogino S
通讯作者：
Ogino S
影响因子：
15.8
作者：
Faca VM;Song KS;Wang H;Zhang Q;Krasnoselsky AL;Newcomb LF;Plentz RR;Gurumurthy S;Redston MS;Pitteri SJ;Pereira-Faca SR;Ireton RC;Katayama H;Glukhova V;Phanstiel D;Brenner DE;Anderson MA;Misek D;Scholler N;Urban ND;Barnett MJ;Edelstein C;Goodman GE;Thornquist MD;McIntosh MW;DePinho RA;Bardeesy N;Hanash SM
通讯作者：
Hanash SM
DOI：
10.1007/s10552-016-0845-z
发表时间：
2017-02
期刊：
Cancer causes & control : CCC
影响因子：
--
作者：
Campbell PT;Rebbeck TR;Nishihara R;Beck AH;Begg CB;Bogdanov AA;Cao Y;Coleman HG;Freeman GJ;Heng YJ;Huttenhower C;Irizarry RA;Kip NS;Michor F;Nevo D;Peters U;Phipps AI;Poole EM;Qian ZR;Quackenbush J;Robins H;Rogan PK;Slattery ML;Smith-Warner SA;Song M;VanderWeele TJ;Xia D;Zabor EC;Zhang X;Wang M;Ogino S
通讯作者：
Ogino S
影响因子：
3.7
作者：
Glass K;Huttenhower C;Quackenbush J;Yuan GC
通讯作者：
Yuan GC