Revisiting social MPE: an integration of molecular pathological epidemiology and social science in the new era of precision medicine.
Revisiting social MPE: an integration of molecular pathological epidemiology and social science in the new era of precision medicine.
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重温社会MPE：在精准医学新时代的分子病理流行病学和社会科学的整合。
DOI：
10.1080/14737159.2021.1952073
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发表时间：
2021-09
影响因子：
5.1
通讯作者：
Ogino S
中科院分区：
文献类型：
--
作者：
Dai J;Nishi A;Tran N;Yamamoto Y;Dewey G;Ugai T;Ogino S
分子病理流行病学(MPE)是研究各种暴露与疾病致病特征之间关系的综合学科领域。随着重大医学教育的不断进步，社会科学及其与健康相关的跨学科领域也得到了迅速发展。越来越多的证据表明，社会人口因素的病态作用。因此，我们最初在2015年提出了社会MPE，旨在阐明社会人口因素的病因作用，并解决全球健康不平等问题。随着分子诊断的无处不在，研究人员有足够的机会利用和开发社会MPE框架。人们对乳腺癌的分子亚型进行了严格的研究，以了解其根源于社会因素。新出现的证据表明，阿尔茨海默病等神经疾病的病原学异质性。呈现不同分子亚型的社会人口学因素的特定模式，对于推进这些异质性疾病的筛查、预防和治疗策略应该是有希望的。本文严格回顾了迄今为止研究乳腺癌和阿尔茨海默病不同分子亚型的种族/民族和社会经济地位差异的文献。随着多组学技术的进步，我们预计社会MPE研究将蓬勃发展，可以解决健康差距，促进个性化分子医学，并提高公众健康。
Molecular pathological epidemiology (MPE) is an integrative disciplinary area examining the relationships between various exposures and pathogenic signatures of diseases. In line with the accelerating advancements in MPE, social science and its health-related interdisciplinary areas have also developed rapidly. Accumulating evidence indicates the pathological role of social-demographic factors. We therefore initially proposed social MPE in 2015, which aims to elucidate etiological roles of social-demographic factors and address health inequalities globally. With the ubiquity of molecular diagnosis, there are ample opportunities for researchers to utilize and develop the social MPE framework. Molecular subtypes of breast cancer have been investigated rigorously for understanding its etiologies rooted from social factors. Emerging evidence indicates pathogenic heterogeneity of neurological disorders such as Alzheimer’s disease. Presenting specific patterns of social-demographic factors across different molecular subtypes should be promising for advancing the screening, prevention, and treatment strategies of those heterogeneous disease. This article rigorously reviewed literatures investigating differences of race/ethnicity and socioeconomic status across molecular subtypes of breast cancer and Alzheimer’s disease to date. With advancements of the multi-omics technologies, we foresee a blooming of social MPE studies, which can address health disparities, advance personalized molecular medicine, and enhance public health.
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影响因子：
2.3
作者：
Camacho-Mercado, Clara L.;Figueroa, Raul;Vega, Irving E.
通讯作者：
Vega, Irving E.
DOI：
10.1007/s10552-016-0845-z
发表时间：
2017-02
期刊：
Cancer causes & control : CCC
影响因子：
--
作者：
Campbell PT;Rebbeck TR;Nishihara R;Beck AH;Begg CB;Bogdanov AA;Cao Y;Coleman HG;Freeman GJ;Heng YJ;Huttenhower C;Irizarry RA;Kip NS;Michor F;Nevo D;Peters U;Phipps AI;Poole EM;Qian ZR;Quackenbush J;Robins H;Rogan PK;Slattery ML;Smith-Warner SA;Song M;VanderWeele TJ;Xia D;Zabor EC;Zhang X;Wang M;Ogino S
通讯作者：
Ogino S
影响因子：
9.9
作者：
Barnes, Lisa L.;Leurgans, Sue;Schneider, Julie A.
通讯作者：
Schneider, Julie A.
影响因子：
8.8
作者：
Amitay, Efrat L.;Carr, Prudence R.;Hoffmeister, Michael
通讯作者：
Hoffmeister, Michael
NCBI GEO：开采数以百万计的表达概况 - 数据库和工具更新。
影响因子：
14.9
作者：
Barrett, Tanya;Troup, Dennis B.;Wilhite, Stephen E.;Ledoux, Pierre;Rudnev, Dmitry;Evangelista, Carlos;Kim, Irene F.;Soboleva, Alexandra;Tomashevsky, Maxim;Edgar, Ron
通讯作者：
Edgar, Ron