A Self-Reported Adherence Measure to Screen for Elevated HIV Viral Load in Pregnant and Postpartum Women on Antiretroviral Therapy.
A Self-Reported Adherence Measure to Screen for Elevated HIV Viral Load in Pregnant and Postpartum Women on Antiretroviral Therapy.
复制标题
DOI：
10.1007/s10461-016-1448-0
复制
发表时间：
2017-02
影响因子：
4.4
通讯作者：
Wilson, Ira B.
中科院分区：
文献类型：
--
作者：
Phillips, Tamsin;Brittain, Kirsty;Mellins, Claude A.;Zerbe, Allison;Remien, Robert H.;Abrams, Elaine J.;Myer, Landon;Wilson, Ira B.
产妇对抗逆转录病毒治疗（ART）的依从性是一个令人关注的问题，监测依从性在资源匮乏的环境中提出了重大挑战。我们调查了南非开普敦接受抗逆转录病毒治疗的艾滋病毒感染孕妇和产后妇女自我报告的依从性（使用简单的三项量表进行测量）与病毒载量（VL）升高之间的关系。这是第一次在非英语环境中使用该量表，并取得了良好的心理测量特征（Cronbach α = 0.79）。在纳入分析的452名女性中，只有12%的人在自我报告量表上报告完全遵守，而92%的人VL <1000拷贝/毫升。VL升高始终与较低的中位依从性评分相关，量表的曲线下面积分别为0.599,0.656和0.642，使用VL截止值分别为≥50，≥1000和≥10000拷贝/mL。这个简单的自我报告依从性量表显示了在这种情况下作为第一阶段依从性筛查的潜力。在普遍接受抗逆转录病毒治疗的时代，低资源环境下的孕产妇依从性监测需要得到重视，这种简单的依从性量表在常规抗逆转录病毒治疗环境中的价值值得进一步调查。
Maternal adherence to antiretroviral therapy (ART) is a concern and monitoring adherence presents a significant challenge in low-resource settings. We investigated the association between self-reported adherence, measured using a simple three-item scale, and elevated viral load (VL) among HIV-infected pregnant and postpartum women on ART in Cape Town, South Africa. This is the first reported use of this scale in a non-English speaking setting and it achieved good psychometric characteristics (Cronbach α = 0.79). Among 452 women included in the analysis, only 12 % reported perfect adherence on the self-report scale, while 92 % had a VL <1000 copies/mL. Having a raised VL was consistently associated with lower median adherence scores and the area under the curve for the scale was 0.599, 0.656 and 0.642 using a VL cut-off of ≥50, ≥1000 and ≥10000 copies/mL, respectively. This simple self-report adherence scale shows potential as a first-stage adherence screener in this setting. Maternal adherence monitoring in low resource settings requires attention in the era of universal ART, and the value of this simple adherence scale in routine ART care settings warrants further investigation.
登录
查看更多内容
影响因子：
56.3
作者：
Baernighausen, Till;Chaiyachati, Krisda;Chimbindi, Natsayi;Peoples, Ashleigh;Haberer, Jessica;Newell, Marie-Louise
通讯作者：
Newell, Marie-Louise
影响因子：
4
作者：
Garfield S;Clifford S;Eliasson L;Barber N;Willson A
通讯作者：
Willson A
影响因子：
3.7
作者：
Hodgson I;Plummer ML;Konopka SN;Colvin CJ;Jonas E;Albertini J;Amzel A;Fogg KP
通讯作者：
Fogg KP
影响因子：
3.8
作者：
Read, Phillip J.;Mandalia, Sundhiya;de Ruiter, Annemiek
通讯作者：
de Ruiter, Annemiek
DOI：
10.1097/01.qai.0000147522.34369.12
发表时间：
2005-04-01
影响因子：
3.6
作者：
Nieuwkerk, PT;Oort, FJ
通讯作者：
Oort, FJ